Evidence map›Paper›PMID 39416845›Full record

ArticleHeliyon2024

Characterizing biomolecular structure features through an innovative elliptical dichroism spectrometry for cancer detection.

Yusuf Asad, Keerthi Priya Jangili, Amara Arshad, Maliha Elma, Komila Rasuleva, Alfred Akinlalu, Tommy Gao, Umamaheswara Rao Tida, Wenjie Xia, Dali Sun

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yusuf AsadBiomedical Engineering Program, North Dakota State University, 1401 Centennial Blvd, Engineering Administration, Room 203, Fargo, ND, 58102, United States.
Keerthi Priya JangiliBiomedical Engineering Program, North Dakota State University, 1401 Centennial Blvd, Engineering Administration, Room 203, Fargo, ND, 58102, United States.
Amara ArshadMaterials and Nanotechnology, North Dakota State University, Fargo, ND 58108, United States.
Maliha ElmaDepartment of Electrical and Computer Engineering, North Dakota State University, 1411 Centennial Blvd., 101S Fargo, ND, 58102, United States.
Komila RasulevaBiomedical Engineering Program, North Dakota State University, 1401 Centennial Blvd, Engineering Administration, Room 203, Fargo, ND, 58102, United States.
Alfred AkinlaluDepartment of Electrical & Computer Engineering, University of Denver, 2155 E. Wesley Ave., Denver, CO, 80210, United States.
Tommy GaoDepartment of Electrical & Computer Engineering, University of Denver, 2155 E. Wesley Ave., Denver, CO, 80210, United States.
Umamaheswara Rao TidaDepartment of Electrical and Computer Engineering, North Dakota State University, 1411 Centennial Blvd., 101S Fargo, ND, 58102, United States.
Wenjie XiaDepartment of Aerospace Engineering, Iowa State University, Ames, IA, 50011, United States.
Dali SunDepartment of Electrical & Computer Engineering, University of Denver, 2155 E. Wesley Ave., Denver, CO, 80210, United States.

Funding

Exosomal Contents Guided Amino Acids Treatment for Pancreatic CancerR21CA270748 · NCI · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI SUN, DALI · 2022 to 2023
$369k
NCI NIH HHS R21 CA270748
6 · The paper itself

Abstract

This research introduces a novel method for evaluating the structural features of biomolecules, utilizing our innovative Elliptical Dichroism (ED) spectrometer specifically designed for stereochemical analysis. By integrating ED spectrometry with autocorrelation (AC) analysis, we investigate the conformational characteristics of biological molecules such as amino acids, proteins, and extracellular vesicles (EVs) induced by elliptically polarized UV absorption. Our streamlined approach offers a cost-effective and portable solution with minimal sample consumption and supports multiple working modes to efficiently characterize biomolecular structures. The insight from this new approach demonstrates potential applications in using biomolecular characterization for cancer detection.

Indexed as

Autocorrelation functionDensity-functional theoryElliptical dichroismMolecular dynamics simulationSpectrometerStereochemical analysisTumor differentiation

Identifiers

PMID39416845
PMCPMC11481634

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.