Evidence map›Paper›PMID 39416578›Full record

ArticleCureus2024

Niacin (Vitamin B3)-Induced Acute Fulminant Hepatic Failure in a 24-Year-Old Female.

Michael Duffy, Gary Zhang, Chanika Ariyawansa, Matthew H Anstey

Abstract readCase Reports
In one paragraph

Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Michael DuffyIntensive Care Medicine, Sir Charles Gairdner Hospital, Perth, AUS.
Gary ZhangIntensive Care Medicine, Sir Charles Gairdner Hospital, Perth, AUS.
Chanika AriyawansaLaboratory Medicine, Sir Charles Gairdner Hospital, Perth, AUS.
Matthew H AnsteyIntensive Care Medicine, The University of Western Australia, Perth, AUS.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute liver failure (ALF) is a rare, life-threatening condition characterized by acute severe liver injury, encephalopathy, and coagulopathy in the absence of prior liver disease. The causes of ALF are broad and varied worldwide, commonly including triggers such as drugs (predominantly paracetamol) in developed countries and viral infections in developing nations. Prompt diagnosis and management are crucial in acute fulminant liver failure as highlighted in this case of a 24-year-old female with ALF secondary to vitamin B3 overdosing. This study further highlights the need for a high degree of clinical suspicion that physicians need to ascertain the cause of acute liver failure, the complexity of its management, and the significant harm unnecessary dietary supplementation can result in. This is a crucial example of why healthcare professionals need to educate their patients about the potential adverse consequences of dietary supplements.

Indexed as

acute fulminant liver failurehepatologyintensive care unit (icu)niacintoxicology and poisoning

Identifiers

PMID39416578
PMCPMC11481423

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.