ArticleAlzheimer's & dementia (Amsterdam, Netherlands)
Apathy and effort-based decision-making in Alzheimer's disease and subjective cognitive impairment.
Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Working Memory Deficits in Hippocampal Amnesia are Associated with Apathy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Apathy, effort-based decisions and brain integrity in Alzheimer's and Parkinson's diseases.Brain : a journal of neurology · 2026Article
- The neural basis of prosocial effort-based decision making in older adults at risk for Alzheimer's disease.medRxiv : the preprint server for health sciences · 2026Article
- Response Facilitation in Dementia Care: Exploring Engagement Through Social Contexts: A Qualitative Study in Dutch Nursing Homes.Healthcare (Basel, Switzerland) · 2026Article
- Predicting apathy using connectome-based models derived from static and dynamic brain connectivity.Social cognitive and affective neuroscience · 2026Article
- Multimodal Neuroimaging Mechanisms of Apathy in Alzheimer's Disease: A Narrative Review of Structural, Functional, and Molecular Evidence.International journal of general medicine · 2026Review
- Self- versus caregiver-reported apathy across neurological disorders.Brain communications · 2025Article
- Objective measures of instrumental activities of daily living and neuropsychiatric symptoms in aging and early-stage Alzheimer's disease.Alzheimer's & dementia (Amsterdam, Netherlands)Article
- Apathy and effort-based decision-making in Alzheimer's disease and subjective cognitive impairment.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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4 authors.
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Abstract
introductionApathy is a significant feature in Alzheimer's disease (AD) and subjective cognitive impairment (SCI), though its mechanisms are not well established.
methodsAn effort-based decision-making (EBDM) framework was applied to investigate apathy in 30 AD patients, 41 SCI participants, and 55 healthy controls (HC). Data were analyzed using a drift-diffusion model (DDM) to uncover latent psychological processes.
resultsSCI participants reported higher apathy than AD patients and HC. However, informant reports of apathy in AD patients were higher than self-reports and indicated significant apathy compared to HC. Both the AD and SCI groups showed reduced sensitivity to effort changes, linked to executive dysfunction in AD and apathy in SCI. Increased resting functional cortical connectivity with the nucleus accumbens (NA) was associated with higher apathy in SCI. DISCUSSION: These results highlight a similar disruption of EBDM in AD and SCI, differentially related to executive functioning in AD and apathy in SCI. Highlights: This is the first study investigating apathy using an effort-based decision-making (EBDM) framework in Alzheimer's disease (AD) and subjective cognitive impairment (SCI).Self-reports underestimate apathy in AD patients when compared to informant reports and healthy controls (HC). SCI participants, in whom self and informant reports were more concordant, also showed higher degrees of apathy.Both AD and SCI groups showed reduced sensitivity to effort.Reduced sensitivity to effort correlates with executive dysfunction in AD and apathy, but not depression, in SCI.Increased nucleus accumbens (ventral striatum) connectivity with the frontoparietal network was associated with higher apathy scores in SCI.The results thus suggest that while AD and SCI can have similar deficits in EBDM, these deficits correlate with distinct clinical manifestations: executive dysfunction in AD and apathy in SCI.
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