ArticleEClinicalMedicine2024
Global burden of dementia in younger people: an analysis of data from the 2021 Global Burden of Disease Study.
Article in EClinicalMedicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Comparisons of acupuncture therapies combining conventional treatment in the management of vascular cognitive impairment: a systematic review and network meta-analysis.Frontiers in aging neuroscience · 2025Pooled it
- Burden of early-onset laryngeal cancer in individuals aged 15-49 years: global, regional, and national estimates from the GBD 2021 study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- Mapping the Young-Onset Dementia Research in the Asia-Pacific Region: A Scoping Review.Asia-Pacific psychiatry : official journal of the Pacific Rim College of Psychiatrists · 2026Article
- Global Trends and Disparities in Early-Onset Dementia: Systematic Analysis and Projection from the Global Burden of Diseases 2021 Study.Neuroepidemiology · 2026Article
- Scientific knowledge about dementia: From the Global South to the world.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Using Photovoice to investigate the lived experiences of family care partners of people living with dementia: What supports their well-being in a care relationship?Frontiers in public health · 2026Article
- Analysis of the Association Between Psychosocial Stressors and Depression Among Family Caregivers of Individuals With Young-Onset Dementia and Late-Onset Dementia: A Cross-Sectional Study.Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society · 2026Article
- Quantifying White Matter Hyperintensities: Automated Volumetry Compared with Visual Grading Scales.Medicina (Kaunas, Lithuania) · 2025Article
- Machine learning approaches to racial/ethnic differences in social determinants of mild cognitive impairment and its progression to dementia in the All of Us Research Program.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Article
- Sleep Disorders in Neurodegenerative Diseases with Dementia: A Comprehensive Review.Journal of clinical medicine · 2025Review
- Race and Ethnicity and Comorbidities Among Medicare Beneficiaries With Young-Onset Dementia.JAMA network open · 2025Article
- Biomolecular Aspects of Reelin in Neurodegenerative Disorders: An Old Candidate for a New Linkage of the Gut-Brain-Eye Axis.International journal of molecular sciences · 2025Review
- Alzheimer's disease and dementia in Japan: Epidemiological trends, regional disparities, and future projections.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- The Role of Genetic, Environmental, and Dietary Factors in Alzheimer's Disease: A Narrative Review.International journal of molecular sciences · 2025Review
- Article
- The hidden in plain sight: global, regional, and national trends in the pediatric burden of Klinefelter syndrome, 1990-2021.Frontiers in genetics · 2025Article
- Global, regional, and national burden of upper respiratory infections, 1990-2021: Findings from the Global Burden of Disease study 2021.Science in One Health · 2024Article
- Determinants of Time to Diagnosis in Young-Onset Dementia.American journal of Alzheimer's disease and other dementiasArticle
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Dementia among younger people is rapidly emerging as a global health concern; however, comprehensive research on its shifting burden trends remains insufficient. Methods: Data on the prevalence, incidence, mortality, and disability-adjusted life years (DALYs) associated with dementia occurring in individuals <70 years were extracted from the Global Burden of Diseases, Injuries, and Risk Factors Study 2021. Average annual percentage changes (AAPCs) were calculated to assess trends in age-specific rates (ASRs), including age-specific prevalence rates (ASPRs), age-specific incidence rates (ASIRs), age-specific mortality rates (ASMRs), and age-specific DALY rates (ASDRs) while young-onset dementia (YOD) burden trends were analyzed. The correlation between ASR/AAPC and the sociodemographic index (SDI) was evaluated. Findings: In 2021, the global prevalence of dementia in individuals <70 years increased by 122.33%, with a 128% increase in new cases since 1990. Concurrently, deaths and DALYs of individuals <70 years with dementia rose by 119.28% and 119.77%, respectively. The AAPCs of YOD ASRs during 1990-2021 initially increased and then decreased with increasing SDI levels, with the highest AAPCs of ASPR (2.20 [95%CI: 2.08-2.32] per 100,000), ASIR (2.25 [95%CI: 2.06-2.45] per 100,000), ASMR (2.04 [95%CI: 1.93-2.15] per 100,000), and ASDR (2.06 [95%CI: 1.99-2.13] per 100,000) observed in middle-SDI levels. Additionally, females <70 years bore a higher burden of dementia globally, and gender differences are still widening. Interpretation: The growth rate of YOD is accelerating, particularly in the middle to high SDI region with females bearing a disproportionately higher burden of YOD. Funding: This work was supported by grants from the National High level Hospital Clinical Research Funding, CAMS Innovation Fund for Medical Sciences, and the National Natural Science Foundation of China.
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