Evidence map›Paper›PMID 39416381›Full record

ArticleFrontiers in physiology2024

Comparing single- and multi-post labeling delays for the measurements of resting cerebral and hippocampal blood flow for cerebrovascular testing in midlife adults.

Kevin P Decker, Faria Sanjana, Nick Rizzi, Mary K Kramer, Alexander M Cerjanic, Curtis L Johnson, Christopher R Martens

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kevin P DeckerDepartment of Kinesiology and Applied Physiology, University of Delaware, Newark, DE, United States.
Faria SanjanaDepartment of Kinesiology and Applied Physiology, University of Delaware, Newark, DE, United States.
Nick RizziDepartment of Kinesiology and Applied Physiology, University of Delaware, Newark, DE, United States.
Mary K KramerDepartment of Biomedical Engineering, University of Delaware, Newark, DE, United States.
Alexander M CerjanicDepartment of Biomedical Engineering, University of Delaware, Newark, DE, United States.
Curtis L JohnsonDepartment of Biomedical Engineering, University of Delaware, Newark, DE, United States.
Christopher R MartensDepartment of Kinesiology and Applied Physiology, University of Delaware, Newark, DE, United States.

Funding

Mechanical integrity of memory systems in mild cognitive impairmentR01AG058853 · NIA · UNIVERSITY OF DELAWARE · PI JOHNSON, CURTIS L · 2018 to 2022
$2.3M
NIA NIH HHS R01 AG058853
6 · The paper itself

Abstract

Objectives: To assess the reliability and validity of measuring resting cerebral blood flow (CBF) and hippocampal CBF using a single-post-labeling delay (PLD) and a multi-PLD pseudo-continuous arterial spin labeling (pCASL) protocol for cerebrovascular reactivity (CVR) testing. Methods: 25 healthy, midlife adults (57 ± 4 years old) were imaged in a Siemens Prisma 3T magnetic resonance imaging (MRI) scanner. Resting CBF and hippocampal CBF were assessed using two pCASL protocols, our modified single-PLD protocol (pCASL-MOD) to accommodate the needs for CVR testing and the multi-PLD Human Connectome Project (HCP) Lifespan protocol to serve as the reference control (pCASL-HCP). During pCASL-MOD, CVR was calculated as the change in CBF from rest to hypercapnia (+9 mmHg increase in end-tidal partial pressure of carbon dioxide [P Results: The pCASL-MOD and pCASL-HCP protocols were significantly correlated for resting GM CBF [r = 0.72; F (1, 23) = 25.24, Conclusion: Our single-PLD pCASL-MOD protocol reliably measured CBF and hippocampal CBF at rest given the significant correlation with the multi-PLD pCASL-HCP protocol. Despite the lower magnitude relative to pCASL-HCP, we recommend using our pCASL-MOD protocol for CVR testing in which an exact estimate of CBF is not required such as the assessment of relative change in CBF to hypercapnia.

Indexed as

and arterial spin labeling (ASL) MRIbrain healthcerebral blood flow (CBF)cerebrovascular reactivity (CVR)magnetic resonance imaging (MRI)

Identifiers

PMID39416381
PMCPMC11480070

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.