Evidence map›Paper›PMID 39416370›Full record

ArticleMedical journal of the Islamic Republic of Iran2024

Effect of Silymarin on Expression of micro-RNA-21 and Matrix Metalloproteinase (MMP) 2 and 9 and Tissue Inhibitors of Matrix Metalloproteinase (TIMP) 1 and 2 in Hepatocellular Carcinoma Cell Line (HepG2).

Maryam Hormozi, Meysam Moulaee, Mahdi Alaee, Nasim Beigi Boroujeni, Mandana Beigi Boroujeni

Abstract read
In one paragraph

Article in Medical journal of the Islamic Republic of Iran, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Maryam HormoziRazi Herbal Medicines Research Center, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.
Meysam MoulaeeStudent Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran.
Mahdi AlaeeStudent Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran.
Nasim Beigi BoroujeniRazi Herbal Medicines Research Center, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.
Mandana Beigi BoroujeniRazi Herbal Medicines Research Center, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.ORCID https://orcid.org/0000-0003-2276-3554

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Silymarin is a flavonolignan that has various medicinal properties such as liver protection, antioxidant, anti-inflammatory, anti-cancer and heart protection activities. The aim of this study was to investigate the effect of silymarin on the expression level of Methods: An Results: The significant up-regulations consisted of Conclusion: The present study showed that silymarin could affect the HepG2 cell line at the gene expression level

Indexed as

ApoptosisCancerGene ExpressionHepatocellular Carcinoma

Identifiers

PMID39416370
PMCPMC11480674

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.