Evidence map›Paper›PMID 39416224›Full record

ArticlebioRxiv : the preprint server for biology2024

In situ crystalline structure of the human eosinophil major basic protein-1.

Jie E Yang, Joshua M Mitchell, Craig A Bingman, Deane F Mosher, Elizabeth R Wright

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jie E YangDepartment of Biochemistry, University of Wisconsin, Madison, WI USA.
Joshua M MitchellDepartments of Biomolecular Chemistry and Medicine, University of Wisconsin, Madison, WI USA.
Craig A BingmanDepartment of Biochemistry, University of Wisconsin, Madison, WI USA.
Deane F MosherDepartments of Biomolecular Chemistry and Medicine, University of Wisconsin, Madison, WI USA.
Elizabeth R WrightDepartment of Biochemistry, University of Wisconsin, Madison, WI USA.ORCID 0000-0003-0712-9475

Funding

The Midwest Center for Cryo-Electron TomographyU24GM139168 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI WRIGHT, ELIZABETH R · 2020 to 2025
$41.7M
Thr Role of Pin1 in AirwayP01HL088594 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI JARJOUR, NIZAR N · 2008 to 2017
$21.0M
RESEARCH TRAINING IN HEMATOLOGYT32HL007899 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI Jane Ellen Churpek · 1998 to 2026
$8.2M
Proteomics of eosinophil activationR01AI125390 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI COON, JOSHUA J, MOSHER, DEANE FREMONT · 2016 to 2019
$1.5M
NHLBI NIH HHS P01 HL088594NHLBI NIH HHS T32 HL007899NIAID NIH HHS R01 AI125390NIGMS NIH HHS U24 GM139168
6 · The paper itself

Abstract

Eosinophils are white blood cells that participate in innate immune responses and have an essential role in the pathogenesis of inflammatory and neoplastic disorders. Upon activation, eosinophils release cytotoxic proteins such as major basic protein-1 (MBP-1) from cytoplasmic secretory granules (SGr) wherein MBP-1 is stored as nanocrystals. How the MBP-1 nanocrystalline core is formed, stabilized, and subsequently mobilized remains unknown. Here, we report the

Identifiers

PMID39416224
PMCPMC11483036

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.