Evidence map›Paper›PMID 39416167›Full record

ArticlebioRxiv : the preprint server for biology2024

Proteomic profiling of the local and systemic immune response to pediatric respiratory viral infections.

Emily Lydon, Christina M Osborne, Brandie D Wagner, Lilliam Ambroggio, J Kirk Harris, Ron Reeder, Todd C Carpenter, Aline B Maddux, Matthew K Leroue, Nadir Yehya and 12 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors.

Emily LydonDepartment of Medicine, University of California San Francisco, San Francisco, CA.ORCID 0000-0003-3510-6254
Christina M OsborneDepartment of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA.ORCID 0000-0002-7452-4734
Brandie D WagnerDepartment of Biostatistics and Informatics, University of Colorado, Colorado School of Public Health, Aurora, CO.
Lilliam AmbroggioSections of Emergency Medicine and Hospital Medicine, Children's Hospital Colorado, Aurora, CO.
J Kirk HarrisDepartment of Pediatrics, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO.
Ron ReederDepartment of Pediatrics, University of Utah, Salt Lake City, UT.
Todd C CarpenterDepartment of Pediatrics, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO.
Aline B MadduxDepartment of Pediatrics, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO.ORCID 0000-0002-0949-4284
Matthew K LeroueDepartment of Pediatrics, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO.
Nadir YehyaDepartment of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA.
Joseph L DeRisiChan Zuckerberg Biohub, San Francisco, CA.
Mark W HallDepartment of Pediatrics, Nationwide Children's Hospital, Columbus, OH.
Athena F ZuppaDepartment of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA.
Joseph CarcilloDepartments of Pediatrics and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA.
Kathleen MeertDepartment of Pediatrics, Children's Hospital of Michigan, Central Michigan University, Detroit, MI.
Anil SapruDepartment of Pediatrics, University of California Los Angeles, Los Angeles, CA.
Murray M PollackDepartment of Pediatrics, Children's National Medical Center and George Washington School of Medicine and Health Sciences, Washington, DC.
Patrick McQuillenDepartment of Pediatrics, University of California San Francisco, San Francisco, CA.ORCID 0000-0002-8837-364X
Daniel A NottermanDepartment of Molecular Biology, Princeton University, Princeton, NJ.
Charles R LangelierDepartment of Medicine, University of California San Francisco, San Francisco, CA.ORCID 0000-0002-6708-4646
Peter M MouraniDepartment of Pediatrics, Critical Care, University of Arkansas for Medical Sciences and Arkansas Children's Hospital, Little Rock, AR.
Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network (CPCCRN)

Funding

The Microbiome, Virome and Host Responses Preceding Ventilator-Associated PneumonR01HL124103 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI MOURANI, PETER M, SONTAG, MARCI K · 2014 to 2017
$2.7M
Collaborative Pediatric Critical Care Research Network (CPCCRN) at Children's NationalUG1HD049981 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI POLLACK, MURRAY MICHAEL, WESSEL, DAVID LLOYD · 2015 to 2020
$1.8M
Pediatric Critical Care Research Network at Children's Hospital of PhiladelphiaUG1HD063108 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI BERG, ROBERT ALLEN, ZUPPA, ATHENA F. · 2015 to 2020
$1.7M
Collaborative Research to Validate Biomarkers of Pediatric ARDSUG1HD083166 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MCQUILLEN, PATRICK SEAN, SAPRU, ANIL · 2015 to 2020
$1.6M
Integrated Host/Microbe Metagenomics to Improve Lower Respiratory Tract Infection Diagnosis in Critically Ill ChildrenR01HL155418 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LANGELIER, CHARLES · 2021 to 2024
$1.6M
Renewal Application for the Childrens Hospital of Pittsburgh Collaborative Pediatric Critical Care Research Network SiteUG1HD049983 · NICHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CARCILLO, JOSEPH A · 2015 to 2020
$1.6M
Collaborative Pediatric Critical Care Research NetworkUG1HD050096 · NICHD · WAYNE STATE UNIVERSITY · PI MEERT, KATHLEEN L. · 2015 to 2020
$1.6M
Collaborative Network Study of Airway Microbiome and Host Responses in Pediatric Respiratory FailureUG1HD083171 · NICHD · UNIVERSITY OF COLORADO DENVER · PI CARPENTER, TODD C · 2015 to 2020
$1.5M
Collaborative Pediatric Critical Care Research Network (UG1)UG1HD083170 · NICHD · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI HALL, MARK W · 2015 to 2020
$1.5M
Profiling the Lung Transcriptome for Precision Diagnosis of Respiratory Infections using Host/Pathogen Metagenomic SequencingK23HL138461 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LANGELIER, CHARLES · 2018 to 2021
$718k
NHLBI NIH HHS K23 HL138461NHLBI NIH HHS R01 HL124103NHLBI NIH HHS R01 HL155418NICHD NIH HHS UG1 HD049981NICHD NIH HHS UG1 HD049983NICHD NIH HHS UG1 HD050096NICHD NIH HHS UG1 HD063108NICHD NIH HHS UG1 HD083166NICHD NIH HHS UG1 HD083170NICHD NIH HHS UG1 HD083171
6 · The paper itself

Abstract

Viral lower respiratory tract infection (vLRTI) is a leading cause of hospitalization and death in children worldwide. Despite this, no studies have employed proteomics to characterize host immune responses to severe pediatric vLRTI in both the lower airway and systemic circulation. To address this gap, gain insights into vLRTI pathophysiology, and test a novel diagnostic approach, we assayed 1,305 proteins in tracheal aspirate (TA) and plasma from 62 critically ill children using SomaScan. We performed differential expression (DE) and pathway analyses comparing vLRTI (n=40) to controls with non-infectious acute respiratory failure (n=22), developed a diagnostic classifier using LASSO regression, and analyzed matched TA and plasma samples. We further investigated the impact of viral load and bacterial coinfection on the proteome. The TA signature of vLRTI was characterized by 200 DE proteins (P

Identifiers

PMID39416167
PMCPMC11482837

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.