Evidence map›Paper›PMID 39416157›Full record

ArticlebioRxiv : the preprint server for biology2024

HDAC Inhibitors recapitulate Human Disease-Associated Microglia Signatures

Verena Haage, John F Tuddenham, Alex Bautista, Charles C White, Frankie Garcia, Ronak Patel, Natacha Comandante-Lou, Victoria Marshe, Rajesh Kumar Soni, Peter A Sims and 3 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Verena HaageCenter for Translational & Computational Neuroimmunology, Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center.ORCID 0000-0001-7569-8421
John F TuddenhamCenter for Translational & Computational Neuroimmunology, Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center.ORCID 0000-0002-0186-2652
Alex BautistaCenter for Translational & Computational Neuroimmunology, Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center.ORCID 0000-0003-4218-7953
Charles C WhiteCenter for Translational & Computational Neuroimmunology, Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center.
Frankie GarciaCenter for Translational & Computational Neuroimmunology, Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center.ORCID 0000-0002-1959-4449
Ronak PatelDepartment of Pathology and Cell Biology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center.ORCID 0000-0001-6782-6470
Natacha Comandante-LouCenter for Translational & Computational Neuroimmunology, Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center.ORCID 0000-0002-7981-7333
Victoria MarsheCenter for Translational & Computational Neuroimmunology, Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center.ORCID 0000-0002-1762-4819
Rajesh Kumar SoniProteomics and Macromolecular Crystallography Shared Resource, Herbert Irving Comprehensive Cancer Center, New York, NY.ORCID 0000-0002-4556-4358
Peter A SimsDepartment of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0002-3921-4837
Vilas MenonCenter for Translational & Computational Neuroimmunology, Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center.ORCID 0000-0002-4096-8601
Andrew A SproulDepartment of Pathology and Cell Biology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center.ORCID 0000-0001-6972-1592
Philip L De JagerCenter for Translational & Computational Neuroimmunology, Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center.ORCID 0000-0002-8057-2505

Funding

Tumor Biology and Microenvironment ProgramP30CA013696 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Anil K Rustgi · 1985 to 2026
$115.3M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007367 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI REINER, STEVEN L · 1985 to 2021
$25.1M
Multi-omic network-directed proteoform discovery, dissection and functional validation to prioritize novel AD therapeutic targetsU01AG061356 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BENNETT, DAVID ALAN, DE JAGER, PHILIP L · 2018 to 2022
$13.7M
Deconstructing and modeling the single cell architecture of the Alzheimer brainRF1AG057473 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BENNETT, DAVID ALAN, DE JAGER, PHILIP L · 2017 to 2018
$4.0M
Neurobiology and Behavior training grantT32MH126036 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Wesley B Grueber · 2020 to 2026
$2.5M
Identifying, validating and targeting AD susceptibility networks in monocytesR01AG048015 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI DE JAGER, PHILIP L · 2014 to 2018
$1.9M
Discovery and validation of genetic variants affecting microglial activation in Alzheimer's diseaseR01AG070438 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI DE JAGER, PHILIP L · 2024 to 2024
$1.6M
Training the Next Generation of Psychiatrists-Scientists for Translational ResearchR25MH129256 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ANTONIA S NEW, Maria De Las Mercedes Perez Rodriguez · 2023 to 2026
$831k
Elucidating transcriptomic and functional heterogeneity of microglia in low-grade glioma and glioma-associated epilepsy.F30CA261090 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI TUDDENHAM, JOHN · 2021 to 2023
$155k
NCI NIH HHS F30 CA261090NCI NIH HHS P30 CA013696NIA NIH HHS R01 AG048015NIA NIH HHS R01 AG070438NIA NIH HHS RF1 AG057473NIA NIH HHS U01 AG061356NIGMS NIH HHS T32 GM007367NIMH NIH HHS R25 MH129256NIMH NIH HHS T32 MH126036
6 · The paper itself

Abstract

Disease-associated microglia (DAM), initially described in mouse models of neurodegenerative diseases, have been classified into two related states; starting from a TREM2-independent DAM1 state to a TREM2 dependent state termed DAM2, with each state being characterized by the expression of specific marker genes

Indexed as

Disease-associated microglia (DAM)functional analysishuman microgliain vitro model systems

Identifiers

PMID39416157
PMCPMC11482930

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.