Evidence map›Paper›PMID 39416143›Full record

ArticlebioRxiv : the preprint server for biology2024

Sm-site containing mRNAs can accept Sm-rings and are downregulated in Spinal Muscular Atrophy.

Anton J Blatnik, Manu Sanjeev, Jacob Slivka, Benjamin Pastore, Caleb M Embree, Wen Tang, Guramrit Singh, Arthur H M Burghes

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Anton J BlatnikORCID 0000-0002-3557-9011
Manu Sanjeev
Jacob Slivka
Benjamin Pastore
Caleb M Embree
Wen TangORCID 0000-0001-6684-5258
Guramrit Singh
Arthur H M Burghes

Funding

Genetic Suppression of SMN Mutations in Spinal Muscular AtrophyR01NS123736 · NINDS · OHIO STATE UNIVERSITY · PI BURGHES, ARTHUR H. M. · 2021 to 2025
$2.5M
Heritable macromolecules in C. elegans germ granulesR35GM142580 · NIGMS · OHIO STATE UNIVERSITY · PI TANG, WEN · 2021 to 2025
$2.0M
Post-transcriptional gene regulation by the exon junction complexR35GM149298 · NIGMS · OHIO STATE UNIVERSITY · PI Guramrit Singh · 2023 to 2026
$1.6M
NIGMS NIH HHS R35 GM142580NIGMS NIH HHS R35 GM149298NINDS NIH HHS R01 NS123736
6 · The paper itself

Abstract

Sm-ring assembly is important for the biogenesis, stability, and function of uridine-rich small nuclear RNAs (U snRNAs) involved in pre-mRNA splicing and histone pre-mRNA processing. Sm-ring assembly is cytoplasmic and dependent upon the Sm-site sequence and structural motif, ATP, and GRAPHICAL ABSTRACT:

Identifiers

PMID39416143
PMCPMC11482833

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.