Evidence map›Paper›PMID 39416108›Full record

ArticlebioRxiv : the preprint server for biology2024

CRISPR tiling deletion screens reveal functional enhancers of neuropsychiatric risk genes and allelic compensation effects (ACE) on transcription.

Xingjie Ren, Lina Zheng, Lenka Maliskova, Tsz Wai Tam, Yifan Sun, Hongjiang Liu, Jerry Lee, Maya Asami Takagi, Bin Li, Bing Ren and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Xingjie RenInstitute for Human Genetics, University of California, San Francisco, San Francisco, CA, USA.
Lina ZhengBioinformatics and Systems Biology Graduate Program, University of California, San Diego, La Jolla, CA, USA.
Lenka MaliskovaInstitute for Human Genetics, University of California, San Francisco, San Francisco, CA, USA.
Tsz Wai TamInstitute for Human Genetics, University of California, San Francisco, San Francisco, CA, USA.
Yifan SunInstitute for Human Genetics, University of California, San Francisco, San Francisco, CA, USA.
Hongjiang LiuInstitute for Human Genetics, University of California, San Francisco, San Francisco, CA, USA.
Jerry LeeInstitute for Human Genetics, University of California, San Francisco, San Francisco, CA, USA.
Maya Asami TakagiInstitute for Human Genetics, University of California, San Francisco, San Francisco, CA, USA.
Bin LiDepartment of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.
Bing RenDepartment of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.
Wei WangBioinformatics and Systems Biology Graduate Program, University of California, San Diego, La Jolla, CA, USA.
Yin ShenInstitute for Human Genetics, University of California, San Francisco, San Francisco, CA, USA.

Funding

Research BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GERMAN, MICHAEL S · 2003 to 2019
$21.8M
High throughput CRISPR-mediated functional validation of regulatory elementsUM1HG009402 · NHGRI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI REN, BING, SHEN, YIN · 2017 to 2021
$8.4M
Illumina NovaSeq 6000 Sequencing SystemS10OD028511 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHOW, ERIC D · 2020 to 2020
$583k
BD FACSAria Fusion Cell SorterS10OD021822 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LEE, MICHAEL R. · 2016 to 2016
$573k
NHGRI NIH HHS UM1 HG009402NIDDK NIH HHS P30 DK063720NIH HHS S10 OD021822NIH HHS S10 OD028511
6 · The paper itself

Abstract

Precise transcriptional regulation is critical for cellular function and development, yet the mechanism of this process remains poorly understood for many genes. To gain a deeper understanding of the regulation of neuropsychiatric disease risk genes, we identified a total of 39 functional enhancers for four dosage-sensitive genes,

Identifiers

PMID39416108
PMCPMC11483005

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.