Evidence map›Paper›PMID 39416100›Full record

ArticlebioRxiv : the preprint server for biology2025

Metastatic organotropism in small cell lung cancer.

Manan Krishnamurthy, Anjali Dhall, Sarthak Sahoo, Christopher W Schultz, Michelle A Baird, Parth Desai, Jacob Odell, Nobuyuki Takahashi, Michael Nirula, Sophie Zhuang and 28 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

38 authors.

Manan KrishnamurthyDevelopmental Therapeutics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD.ORCID 0000-0001-8906-0533
Anjali DhallDevelopmental Therapeutics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD.ORCID 0000-0002-0400-2084
Sarthak SahooDepartment of Bioengineering, Indian Institute of Science, Bangalore, India.ORCID 0000-0002-7771-5894
Christopher W SchultzDevelopmental Therapeutics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD.ORCID 0000-0001-5731-2847
Michelle A BairdCell and Developmental Biology Center, National Heart, Lung and Blood Institute, National Institutes of Health; Bethesda, USA.ORCID 0009-0006-8461-4035
Parth DesaiDevelopmental Therapeutics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD.ORCID 0000-0002-7715-4919
Jacob OdellWeill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853, USA; Graduate Field of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, NY 14853, USA.ORCID 0000-0001-9043-1338
Nobuyuki TakahashiDevelopmental Therapeutics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD.ORCID 0000-0002-8592-6528
Michael NirulaDevelopmental Therapeutics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD.ORCID 0009-0003-5861-0872
Sophie ZhuangDevelopmental Therapeutics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Yue HuangDevelopmental Therapeutics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Brett SchroederDevelopmental Therapeutics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD.ORCID 0000-0001-6019-2022
Yang ZhangDevelopmental Therapeutics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Maria Sebastian ThomasDevelopmental Therapeutics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Christophe RedonDevelopmental Therapeutics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD.ORCID 0000-0003-2799-2778
Christina RobinsonAnimal Research Technical Support, Laboratory Animal Sciences Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, NIH, Frederick, MD 21701.
Lai ThangAnimal Research Technical Support, Laboratory Animal Sciences Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, NIH, Frederick, MD 21701.
Lilia IlevaSmall Animal Imaging Program, Laboratory Animal Sciences Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21701, USA.ORCID 0000-0001-8286-8396
Nimit L PatelSmall Animal Imaging Program, Laboratory Animal Sciences Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21701, USA.ORCID 0000-0002-8251-7155
Joseph D KalenSmall Animal Imaging Program, Laboratory Animal Sciences Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21701, USA.
Alice-Anaïs VarletWeill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853, USA; Graduate Field of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, NY 14853, USA.
Noam Zuela-SopilniakWeill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853, USA; Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA.ORCID 0000-0001-6324-1184
Ankita JhaCell and Developmental Biology Center, National Heart, Lung and Blood Institute, National Institutes of Health; Bethesda, USA.ORCID 0000-0003-4921-5136
Darawalee WangsaGenetics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.
Donna ButcherMolecular Histopathology Laboratory, Laboratory of Animal Sciences Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Tamara MorganMolecular Histopathology Laboratory, Laboratory of Animal Sciences Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Alyah N AfzalLaboratory Animal Sciences Program, Genome Modification Core, Frederick National Laboratory for Cancer Research, Frederick, USA.
Raj ChariLaboratory Animal Sciences Program, Genome Modification Core, Frederick National Laboratory for Cancer Research, Frederick, USA.ORCID 0000-0002-2216-313X
Karim BaktiarGenetics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.
Suresh KumarDevelopmental Therapeutics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Lorinc PongorDevelopmental Therapeutics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD.ORCID 0000-0001-5917-4628
Simone DifilippantonioAnimal Research Technical Support, Laboratory Animal Sciences Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, NIH, Frederick, MD 21701.
Mirit I AladjemDevelopmental Therapeutics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Yves PommierDevelopmental Therapeutics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Mohit Kumar JollyDepartment of Bioengineering, Indian Institute of Science, Bangalore, India.
Jan LammerdingWeill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853, USA; Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA.ORCID 0000-0003-4335-8611
Ajit Kumar SharmaDevelopmental Therapeutics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD.ORCID 0000-0002-4811-7342
Anish ThomasDevelopmental Therapeutics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD.ORCID 0000-0003-3293-3115

Funding

Exploiting DNA Replicative Stress for Novel Small Cell Lung Cancer TherapiesZIABC011793 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI THOMAS, ANISH · 2018 to 2025
$16.4M
Nuclear mechanobiology in confined migration (equipment supplement 2026)R35GM153257 · NIGMS · CORNELL UNIVERSITY · PI Jan Lammerding · 2024 to 2026
$1.3M
Intramural NIH HHS ZIA BC011793NCI NIH HHS HHSN261201500003CNCI NIH HHS HHSN261201500003INIGMS NIH HHS R35 GM153257
6 · The paper itself

Abstract

Metastasis is the leading cause of cancer-related deaths, yet its regulatory mechanisms are not fully understood. Small-cell lung cancer (SCLC) is the most metastatic form of lung cancer, with most patients presenting with widespread disease, making it an ideal model for studying metastasis. However, the lack of suitable preclinical models has limited such studies. We utilized rapid autopsy-derived tumors to develop xenograft models that mimic key features of SCLC, including histopathology, rapid and widespread development of metastasis to the liver, brain, adrenal, bone marrow, and kidneys within weeks, and response to chemotherapy. By integrating in vivo lineage selection with comprehensive bulk and single cell multiomic profiling of transcriptomes and chromatin accessibility, we identified critical cellular programs driving metastatic organotropism to the liver and brain, the most common sites of SCLC metastasis. Our findings reveal the key role of nuclear-cytoskeletal interactions in SCLC liver metastasis. Specifically, the loss of the nuclear envelope protein lamin A/C, encoded by the

Identifiers

PMID39416100
PMCPMC11483079

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.