Evidence map›Paper›PMID 39416092›Full record

ArticlebioRxiv : the preprint server for biology2024

mRNA-based influenza vaccine expands breadth of B cell response in humans.

Hanover C Matz, Tae-Geun Yu, Julian Q Zhou, Lowrey Peyton, Anders Madsen, Fangjie Han, Aaron J Schmitz, Stephen C Horvath, Kritika Dixit, Hunter K Keplinger and 11 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors.

Hanover C MatzDepartment of Pathology and Immunology, Washington University School of Medicine; St. Louis, MO 63110, USA.
Tae-Geun YuThayer School of Engineering, Dartmouth College; Hanover, NH 03755, USA.
Julian Q ZhouDepartment of Pathology and Immunology, Washington University School of Medicine; St. Louis, MO 63110, USA.
Lowrey PeytonQuantitative Biomedical Sciences Program, Dartmouth College; Lebanon, NH 03756, USA.
Anders MadsenInfluenza Centre, Department of Clinical Science, University of Bergen; 5021 Bergen, Norway.
Fangjie HanDepartment of Pathology and Immunology, Washington University School of Medicine; St. Louis, MO 63110, USA.
Aaron J SchmitzDepartment of Pathology and Immunology, Washington University School of Medicine; St. Louis, MO 63110, USA.
Stephen C HorvathDepartment of Pathology and Immunology, Washington University School of Medicine; St. Louis, MO 63110, USA.
Kritika DixitDepartment of Pathology and Immunology, Washington University School of Medicine; St. Louis, MO 63110, USA.
Hunter K KeplingerDepartment of Pathology and Immunology, Washington University School of Medicine; St. Louis, MO 63110, USA.
Benjamin S StrnadMallinckrodt Institute of Radiology, Washington University School of Medicine; St Louis, MO 63110, USA.
Mark J HoeggerMallinckrodt Institute of Radiology, Washington University School of Medicine; St Louis, MO 63110, USA.
William D MiddletonMallinckrodt Institute of Radiology, Washington University School of Medicine; St Louis, MO 63110, USA.
Michael K KlebertInfectious Disease Clinical Research Unit, Washington University School of Medicine; St Louis, MO 63110, USA.
Nina H LinModerna, Inc.; Cambridge, MA 02142, USA.
Raffael NachbagauerModerna, Inc.; Cambridge, MA 02142, USA.
Robert ParisModerna, Inc.; Cambridge, MA 02142, USA.
Jackson S TurnerDepartment of Pathology and Immunology, Washington University School of Medicine; St. Louis, MO 63110, USA.
Rachel M PrestiInfectious Disease Clinical Research Unit, Washington University School of Medicine; St Louis, MO 63110, USA.
Jiwon LeeThayer School of Engineering, Dartmouth College; Hanover, NH 03755, USA.
Ali H EllebedyDepartment of Pathology and Immunology, Washington University School of Medicine; St. Louis, MO 63110, USA.ORCID 0000-0002-6129-2532

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0M
COLLABORATIVE INFLUENZA VACCINE INNOVATION CENTER: UNIVERSAL INFLUENZA VACCINE RESEARCH75N93019C00051 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KRAMMER, FLORIAN · 2019 to 2025
$105.4M
NIAID Centers of Excellence for Influenza Research and Response: Universal Influenza Vaccine Research Activities75N93021C00014 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GARCIA-SASTRE, ADOLFO · 2021 to 2025
$62.6M
Household Respiratory Virus SARS-CoV-2 Transmission and Immunity Sub-Study (HRTS)U01AI144616 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI GORDON, AUBREE L, THOMAS, PAUL G. · 2019 to 2025
$43.7M
Virology CoreP01AI089618 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI STEPHEN COPLAN HARRISON · 2011 to 2026
$40.0M
Understanding the role of RNA-binding protein mutations in cancerP20GM113132 · NIGMS · DARTMOUTH COLLEGE · PI MIERKE, DALE F · 2016 to 2025
$25.9M
Infectious Diseases/Basic Microbial Pathogenic MechanismsT32AI007172 · NIAID · WASHINGTON UNIVERSITY · PI Daniel E. Goldberg, JENNIFER A PHILIPS · 1985 to 2026
$13.0M
Programming Durable Immune Responses To VaccinationU01AI141990 · NIAID · WASHINGTON UNIVERSITY · PI Ali Hassan Ellebedy · 2019 to 2026
$5.3M
NCI NIH HHS P30 CA091842NIAID NIH HHS 75N93019C00051NIAID NIH HHS 75N93021C00014NIAID NIH HHS P01 AI089618NIAID NIH HHS T32 AI007172NIAID NIH HHS U01 AI141990NIAID NIH HHS U01 AI144616NIGMS NIH HHS P20 GM113132
6 · The paper itself

Abstract

Eliciting broad and durable antibody responses against rapidly evolving pathogens like influenza viruses remains a formidable challenge

Identifiers

PMID39416092
PMCPMC11483064

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.