Evidence map›Paper›PMID 39416086›Full record

ArticlebioRxiv : the preprint server for biology2024

Isotope Encoded chemical Imaging Identifies Amyloid Plaque Age Dependent Structural Maturation, Synaptic Loss, and Increased Toxicity.

Jack I Wood, Maciej Dulewicz, Junyue Ge, Katie Stringer, Alicja Szadziewska, Sneha Desai, Srinivas Koutarapu, Haady B Hajar, Kaj Blennow, Henrik Zetterberg and 4 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jack I WoodDepartment of Psychiatry and Neurochemistry, Sahlgrenska Academy at the University of Gothenburg, Mölndal Hospital, House V, S-431 80 Mölndal, Sweden.ORCID 0000-0001-6049-4020
Maciej DulewiczDepartment of Psychiatry and Neurochemistry, Sahlgrenska Academy at the University of Gothenburg, Mölndal Hospital, House V, S-431 80 Mölndal, Sweden.
Junyue GeDepartment of Psychiatry and Neurochemistry, Sahlgrenska Academy at the University of Gothenburg, Mölndal Hospital, House V, S-431 80 Mölndal, Sweden.
Katie StringerDepartment of Psychiatry and Neurochemistry, Sahlgrenska Academy at the University of Gothenburg, Mölndal Hospital, House V, S-431 80 Mölndal, Sweden.
Alicja SzadziewskaDepartment of Psychiatry and Neurochemistry, Sahlgrenska Academy at the University of Gothenburg, Mölndal Hospital, House V, S-431 80 Mölndal, Sweden.
Sneha DesaiDepartment of Psychiatry and Neurochemistry, Sahlgrenska Academy at the University of Gothenburg, Mölndal Hospital, House V, S-431 80 Mölndal, Sweden.
Srinivas KoutarapuDepartment of Psychiatry and Neurochemistry, Sahlgrenska Academy at the University of Gothenburg, Mölndal Hospital, House V, S-431 80 Mölndal, Sweden.
Haady B HajarDepartment of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London, United Kingdom.
Kaj BlennowDepartment of Psychiatry and Neurochemistry, Sahlgrenska Academy at the University of Gothenburg, Mölndal Hospital, House V, S-431 80 Mölndal, Sweden.
Henrik ZetterbergDepartment of Psychiatry and Neurochemistry, Sahlgrenska Academy at the University of Gothenburg, Mölndal Hospital, House V, S-431 80 Mölndal, Sweden.
Damian M CummingsDepartment of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London, United Kingdom.ORCID 0000-0001-5567-0907
Jeffrey N SavasDepartment of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Frances A EdwardsDepartment of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London, United Kingdom.
Jörg HanriederDepartment of Psychiatry and Neurochemistry, Sahlgrenska Academy at the University of Gothenburg, Mölndal Hospital, House V, S-431 80 Mölndal, Sweden.

Funding

Understanding Amyloid Pathology - Multiomic Activity Imaging of Plaque Formation Dynamics (AmyMAP)R01AG078796 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Jeffrey Nicholas Savas · 2022 to 2026
$2.7M
Human in vivo stable isotope labeling kinetics (iSILK) to quantify brain amyloid plaque kineticsR21AG078538 · NIA · WASHINGTON UNIVERSITY · PI HANRIEDER, JORG, SCHWETYE, KATHERINE · 2022 to 2022
$411k
Insights into Amyloid Pathogenicity DynamicsR21AG080705 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI HANRIEDER, JORG, SAVAS, JEFFREY NICHOLAS · 2023 to 2024
$401k
NIA NIH HHS R01 AG078796NIA NIH HHS R21 AG078538NIA NIH HHS R21 AG080705
6 · The paper itself

Abstract

It is of critical importance to our understanding of Alzheimer's disease (AD) pathology to determine how key pathological factors are interconnected and implicated in nerve cell death, clinical symptoms, and disease progression. The formation of extracellular beta-amyloid (Aβ) plaques is the major pathological hallmark of AD and Aβ has been suggested to be a critical inducer of AD, driving disease pathogenesis. Exactly how Aβ plaque formation begins and how ongoing plaque deposition proceeds and initiates subsequent neurotoxic mechanisms is not well understood. The primary aim of our research is to elucidate the biochemical processes underlying early Aβ plaque formation in brain tissue. We recently introduced a chemical imaging paradigm based on mass spectrometry imaging (MSI) and metabolic isotope labelling to follow stable isotope labelling kinetics (iSILK) in vivo to track the in vivo build-up and deposition of Aβ. Herein, knock-in Aβ mouse models (

Indexed as

Alzheimer’s diseaseamyloidhyperspectral microscopymass spectrometry imagingspatial transcriptomicsstable isotope labelling kinetics

Identifiers

PMID39416086
PMCPMC11482761

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.