Evidence map›Paper›PMID 39416068›Full record

ArticlebioRxiv : the preprint server for biology2024

TAOK2 Drives Opposing Cilia Length Deficits in 16p11.2 Deletion and Duplication Carriers.

Amy Ferreccio, Sujin Byeon, Moira Cornell, Juan Oses-Prieto, Aditi Deshpande, Lauren A Weiss, Alma Burlingame, Smita Yadav

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Amy FerreccioDepartment of Pharmacology, University of Washington, Seattle, WA 98195.
Sujin ByeonGraduate Program in Neuroscience, University of Washington, Seattle, WA 98195.
Moira CornellDepartment of Pharmacology, University of Washington, Seattle, WA 98195.
Juan Oses-PrietoDepartment of Pharmaceutical Chemistry, University of California, San Francisco, CA 94195.
Aditi DeshpandeDepartment of Psychiatry, Weill Institute for Neurosciences, University of California, San Francisco, CA 94195.
Lauren A WeissDepartment of Psychiatry, Weill Institute for Neurosciences, University of California, San Francisco, CA 94195.
Alma BurlingameDepartment of Pharmaceutical Chemistry, University of California, San Francisco, CA 94195.
Smita YadavDepartment of Pharmacology, University of Washington, Seattle, WA 98195.

Funding

TAOK2 Kinase Signaling in Human Neural Stem Cell DevelopmentR01MH121674 · NIMH · UNIVERSITY OF WASHINGTON · PI YADAV, SMITA · 2020 to 2024
$2.2M
NIMH NIH HHS R01 MH121674
6 · The paper itself

Abstract

Copy number variation (CNV) in the 16p11.2 (BP4-BP5) genomic locus is strongly associated with autism. Carriers of 16p11.2 deletion and duplication exhibit several common behavioral and social impairments, yet, show opposing brain structural changes and body mass index. To determine cellular mechanisms that might contribute to these opposing phenotypes, we performed quantitative tandem mass tag (TMT) proteomics on human dorsal forebrain neural progenitor cells (NPCs) differentiated from induced pluripotent stem cells (iPSC) derived from 16p11.2 CNV carriers. Differentially phosphorylated proteins between unaffected individuals and 16p11.2 CNV carriers were significantly enriched for centrosomal and cilia proteins. Deletion patient-derived NPCs show increased primary cilium length compared to unaffected individuals, while stunted cilium growth was observed in 16p11.2 duplication NPCs. Through cellular shRNA and overexpression screens in human iPSC derived NPCs, we determined the contribution of genes within the 16p11.2 locus to cilium length. TAOK2

Identifiers

PMID39416068
PMCPMC11482803

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.