ArticlebioRxiv : the preprint server for biology2025
Mechanism of the Dual Action Self-Potentiating Antitubercular Drug Morphazinamide.
Lev Ostrer, Taylor A Crooks, Michael D Howe, Sang Vo, Ziyi Jia, Pooja Hegde, Nathan Schacht, Courtney C Aldrich, Anthony D Baughn
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
9 authors.
Lev OstrerDepartment of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, Minnesota USA.ORCID 0000-0001-8047-393X Taylor A CrooksDepartment of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, Minnesota USA.ORCID 0000-0001-7608-1992 Michael D HoweDepartment of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, Minnesota USA.
Sang VoDepartment of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, Minnesota USA.
Ziyi JiaDepartment of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, Minnesota USA.ORCID 0000-0001-8279-5561 Pooja HegdeDepartment of Medicinal Chemistry, College of Pharmacy, University of Minnesota Medical School, Minneapolis, Minnesota USA.
Nathan SchachtDepartment of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, Minnesota USA.
Courtney C AldrichDepartment of Medicinal Chemistry, College of Pharmacy, University of Minnesota Medical School, Minneapolis, Minnesota USA.
Anthony D BaughnDepartment of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, Minnesota USA.ORCID 0000-0003-1188-4238 Funding
TRAINING-PULMONARY CELL &MOLECULAR BIOLOGY &PHYSIOLOGYT32HL007741 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI DUDLEY, R. ADAMS, INGBAR, DAVID H · 1994 to 2023
$13.9MMEDICAL SCIENTIST TRAINING PROGRAMT32GM008244 · NIGMS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI SHIMIZU, YOJI · 1988 to 2024
$13.6MThe impact of pyrazinamide on metabolism in Mycobacterium tuberculosis.R01AI123146 · NIAID · UNIVERSITY OF MINNESOTA · PI BAUGHN, ANTHONY D · 2016 to 2025
$4.3MNHLBI NIH HHS T32 HL007741NIAID NIH HHS R01 AI123146NIGMS NIH HHS T32 GM008244
6 · The paper itselfAbstract
Pyrazinamide (PZA) is a cornerstone of first-line antitubercular drug therapy and is unique in its ability to kill nongrowing populations of
Identifiers
PMID39416067
PMCPMC11482805
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