Evidence map›Paper›PMID 39416065›Full record

ArticlebioRxiv : the preprint server for biology2024

Structural insights into inhibitor mechanisms on immature HIV-1 Gag lattice revealed by high-resolution

Chunxiang Wu, Megan E Meuser, Juan S Rey, Hamed Meshkin, Rachel Yang, Swapnil Chandrakant Devarkar, Christian Freniere, Jiong Shi, Christopher Aiken, Juan R Perilla and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Chunxiang WuDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA.ORCID 0000-0002-8635-1578
Megan E MeuserDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA.ORCID 0000-0002-1544-606X
Juan S ReyDepartment of Chemistry and Biochemistry, University of Delaware, Newark, DE, USA.
Hamed MeshkinDepartment of Chemistry and Biochemistry, University of Delaware, Newark, DE, USA.
Rachel YangDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA.
Swapnil Chandrakant DevarkarDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA.
Christian FreniereDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA.
Jiong ShiDepartment of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
Christopher AikenDepartment of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
Juan R PerillaDepartment of Chemistry and Biochemistry, University of Delaware, Newark, DE, USA.
Yong XiongDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA.ORCID 0000-0001-9625-9313

Funding

Project 3. IntegrationU54AI170791 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Zandrea Ambrose · 2022 to 2026
$30.6M
PREDOCTORAL PROGRAM IN BIOPHYSICST32GM008283 · NIGMS · YALE UNIVERSITY · PI XIONG, YONG · 1988 to 2022
$10.5M
Determining the molecular mechanisms of HIV-1 maturationR01AI178846 · NIAID · UNIVERSITY OF DELAWARE · PI Juan Roberto Perilla Jimenez · 2023 to 2026
$2.3M
NIAID NIH HHS R01 AI178846NIAID NIH HHS U54 AI170791NIGMS NIH HHS T32 GM008283
6 · The paper itself

Abstract

HIV-1 inhibitors, such as Bevirimat (BVM) and Lenacapavir (LEN), block the production and maturation of infectious virions. However, their mechanisms remain unclear due to the absence of high-resolution structures for BVM complexes and LEN's structural data being limited to the mature capsid. Utilizing perforated virus-like particles (VLPs) produced from mammalian cells, we developed an approach to determine

Identifiers

PMID39416065
PMCPMC11483028

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.