Evidence map›Paper›PMID 39416004›Full record

ArticlebioRxiv : the preprint server for biology2024

Enhanced RNA-targeting CRISPR-Cas technology in zebrafish.

Ismael Moreno-Sanchez, Luis Hernandez-Huertas, Daniel Nahon-Cano, Carlos Gomez-Marin, Pedro Manuel Martinez-García, Anthony J Treichel, Laura Tomas-Gallardo, Gabriel da Silva Pescador, Gopal Kushawah, Alejandro Díaz-Moscoso and 8 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Ismael Moreno-SanchezAndalusian Center for Developmental Biology (CABD), Pablo de Olavide University/CSIC/Junta de Andalucía, Ctra. Utrera Km.1, 41013, Seville, Spain.ORCID 0000-0001-5606-4028
Luis Hernandez-HuertasAndalusian Center for Developmental Biology (CABD), Pablo de Olavide University/CSIC/Junta de Andalucía, Ctra. Utrera Km.1, 41013, Seville, Spain.
Daniel Nahon-CanoAndalusian Center for Developmental Biology (CABD), Pablo de Olavide University/CSIC/Junta de Andalucía, Ctra. Utrera Km.1, 41013, Seville, Spain.
Carlos Gomez-MarinAndalusian Center for Developmental Biology (CABD), Pablo de Olavide University/CSIC/Junta de Andalucía, Ctra. Utrera Km.1, 41013, Seville, Spain.
Pedro Manuel Martinez-GarcíaAndalusian Center for Developmental Biology (CABD), Pablo de Olavide University/CSIC/Junta de Andalucía, Ctra. Utrera Km.1, 41013, Seville, Spain.
Anthony J TreichelStowers Institute for Medical Research, 1000 E 50th St, Kansas City, MO 64110, USA.
Laura Tomas-GallardoAndalusian Center for Developmental Biology (CABD), Pablo de Olavide University/CSIC/Junta de Andalucía, Ctra. Utrera Km.1, 41013, Seville, Spain.
Gabriel da Silva PescadorStowers Institute for Medical Research, 1000 E 50th St, Kansas City, MO 64110, USA.
Gopal KushawahStowers Institute for Medical Research, 1000 E 50th St, Kansas City, MO 64110, USA.
Alejandro Díaz-MoscosoAndalusian Center for Developmental Biology (CABD), Pablo de Olavide University/CSIC/Junta de Andalucía, Ctra. Utrera Km.1, 41013, Seville, Spain.
Alejandra Cano-RuizAndalusian Center for Developmental Biology (CABD), Pablo de Olavide University/CSIC/Junta de Andalucía, Ctra. Utrera Km.1, 41013, Seville, Spain.
John A WalkerSynthego Corporation, Redwood City, CA, USA.
Manuel J MuñozAndalusian Center for Developmental Biology (CABD), Pablo de Olavide University/CSIC/Junta de Andalucía, Ctra. Utrera Km.1, 41013, Seville, Spain.
Kevin HoldenSynthego Corporation, Redwood City, CA, USA.
Joan GalceránInstituto de Neurociencias (CSIC-UMH), Sant Joan d'Alacant, Alicante, Spain.
María Ángela NietoInstituto de Neurociencias (CSIC-UMH), Sant Joan d'Alacant, Alicante, Spain.
Ariel BazziniStowers Institute for Medical Research, 1000 E 50th St, Kansas City, MO 64110, USA.
Miguel A Moreno-MateosAndalusian Center for Developmental Biology (CABD), Pablo de Olavide University/CSIC/Junta de Andalucía, Ctra. Utrera Km.1, 41013, Seville, Spain.ORCID 0000-0001-5723-0569

Funding

Small translated ORFs in the 3'UTR enhance translation in vertebratesR01GM136849 · NIGMS · STOWERS INSTITUTE FOR MEDICAL RESEARCH · PI BAZZINI, ARIEL · 2021 to 2025
$2.0M
CRISPR-Cas13d: Transgenic zebrafish lines toknockdown mRNAR21OD034161 · OD · STOWERS INSTITUTE FOR MEDICAL RESEARCH · PI BAZZINI, ARIEL · 2023 to 2024
$454k
Opening small packages: unraveling roles for microproteins during early vertebrate developmentF31HD110268 · NICHD · STOWERS INSTITUTE FOR MEDICAL RESEARCH · PI TREICHEL, ANTHONY J · 2023 to 2025
$98k
NICHD NIH HHS F31 HD110268NIGMS NIH HHS R01 GM136849NIH HHS R21 OD034161
6 · The paper itself

Abstract

CRISPR-Cas13 systems are widely used in basic and applied sciences. However, its application has recently generated controversy due to collateral activity in mammalian cells and mouse models. Moreover, its efficiency could be improved

Indexed as

Cas13Cas7–11collateral activityCRISPR-CasRNA-targetingzebrafish

Identifiers

PMID39416004
PMCPMC11482928

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.