Evidence map›Paper›PMID 39416003›Full record

ArticlebioRxiv : the preprint server for biology2025

Gut Bacteria Metabolize Natural and Synthetic Steroid Hormones via the Reductive OsrABC Pathway.

Christian Jacoby, Kaylie Scorza, Lia Ecker, Paola Nol Bernardino, Alexander S Little, Mary McMillin, Ramanujam Ramaswamy, Anitha Sundararajan, Ashley M Sidebottom, Huaiying Lin and 4 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Christian JacobyDuchossois Family Institute, University of Chicago, Chicago, IL 60637, USA.
Kaylie ScorzaDuchossois Family Institute, University of Chicago, Chicago, IL 60637, USA.
Lia EckerDuchossois Family Institute, University of Chicago, Chicago, IL 60637, USA.
Paola Nol BernardinoDuchossois Family Institute, University of Chicago, Chicago, IL 60637, USA.
Alexander S LittleDuchossois Family Institute, University of Chicago, Chicago, IL 60637, USA.
Mary McMillinDuchossois Family Institute, University of Chicago, Chicago, IL 60637, USA.
Ramanujam RamaswamyDuchossois Family Institute, University of Chicago, Chicago, IL 60637, USA.
Anitha SundararajanDuchossois Family Institute, University of Chicago, Chicago, IL 60637, USA.
Ashley M SidebottomDuchossois Family Institute, University of Chicago, Chicago, IL 60637, USA.
Huaiying LinDuchossois Family Institute, University of Chicago, Chicago, IL 60637, USA.
Keith Dufault-ThompsonNational Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA.
Brantley HallDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, College Park, MD 20742, USA.
Xiaofang JiangNational Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA.ORCID 0000-0002-0955-8284
Samuel H LightDuchossois Family Institute, University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0002-8074-1348

Funding

ULTRASTRUCTURE AND CYTOMORPHOLOGY COREP30DK042086 · NIDDK · UNIVERSITY OF CHICAGO · PI CHANG, EUGENE B · 1990 to 2025
$29.8M
Ecological niche assignment in the gut microbiome on an ecosystem-level scaleR35GM146969 · NIGMS · UNIVERSITY OF CHICAGO · PI Samuel Light · 2022 to 2026
$2.1M
NIDDK NIH HHS P30 DK042086NIGMS NIH HHS R35 GM146969
6 · The paper itself

Abstract

Steroid hormone metabolism by the gut microbiome affects host physiology, but the underlying microbial pathways remain incompletely understood. Here, we isolate a novel human gut bacterium,

Identifiers

PMID39416003
PMCPMC11482826

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.