Evidence map›Paper›PMID 39415993›Full record

ArticlebioRxiv : the preprint server for biology2024

The molecular chronology of mammary epithelial cell fate switching.

Queralt Vallmajo-Martin, Zhibo Ma, Sumana Srinivasan, Divya Murali, Christopher Dravis, Kavitha Mukund, Shankar Subramaniam, Geoffrey M Wahl, Nikki K Lytle

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Queralt Vallmajo-MartinGene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.ORCID 0000-0002-2352-7177
Zhibo MaGene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.ORCID 0000-0002-5801-0354
Sumana SrinivasanDepartment of Bioengineering, University of California, San Diego, La Jolla, CA, USA.
Divya MuraliDepartment of Bioengineering, University of California, San Diego, La Jolla, CA, USA.
Christopher DravisGene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.
Kavitha MukundDepartment of Bioengineering, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0002-3570-2315
Shankar SubramaniamDepartment of Bioengineering, University of California, San Diego, La Jolla, CA, USA.
Geoffrey M WahlGene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.ORCID 0000-0003-3658-2279
Nikki K LytleDepartment of Surgery, Medical College of Wisconsin Cancer Center, Milwaukee, WI, USA.ORCID 0000-0002-9936-4212

Funding

Combining single cell approaches and a developmental perspective to discover stem cell control circuits and the cellular and molecular bases of cancer heterogeneityR35CA197687 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI WAHL, GEOFFREY MYLES · 2015 to 2021
$7.8M
The CFDE WorkbenchOT2OD036435 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MA'AYAN, AVI, SUBRAMANIAM, SHANKAR · 2023 to 2025
$7.2M
San Diego Nathan Shock CenterP30AG068635 · NIA · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI SHARPEE, TATYANA O. · 2020 to 2024
$6.0M
Biomedical Data Commons Workbench (BDCW)OT2OD030544 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SUBRAMANIAM, SHANKAR · 2020 to 2024
$3.2M
BD FACSAria Fusion for Flow Cytometry Core FacilityS10OD023689 · OD · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI ZHENG, YE · 2018 to 2018
$530k
NCI NIH HHS R35 CA197687NIA NIH HHS P30 AG068635NIH HHS OT2 OD030544NIH HHS OT2 OD036435NIH HHS S10 OD023689Wellcome Trust
6 · The paper itself

Abstract

The adult mammary gland is maintained by lineage-restricted progenitor cells through pregnancy, lactation, involution, and menopause. Injury resolution, transplantation-associated mammary gland reconstitution, and tumorigenesis are unique exceptions, wherein mammary basal cells gain the ability to reprogram to a luminal state. Here, we leverage newly developed cell-identity reporter mouse strains, and time-resolved single-cell epigenetic and transcriptomic analyses to decipher the molecular programs underlying basal-to-luminal fate switching

Indexed as

cell plasticitydedifferentiationfacultative progenitormammary glandmultiome resourcesingle-cell RNA-sequencingsingle-nucleus ATAC-sequencingtissue injury repairtransdifferentiation

Identifiers

PMID39415993
PMCPMC11482796

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.