Evidence map›Paper›PMID 39415921›Full record

ArticleEJHaem2024

Antiphospholipid syndrome, monoclonal gammopathy, and cryoglobulinemia overlap leading to recurrent cutaneous microvascular thrombosis: A case report and retrospective cohort study.

Alexandra Bohm, Bo Angela Wan, Amir Karin, Lauren J Lee, Agnes Y Y Lee, Edward M Conway, Chieh Min Benjamin Lai

Abstract read
In one paragraph

Article in EJHaem, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Monoclonal Gammopathy of Thrombotic Significance.American journal of hematology · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alexandra BohmDepartment of Medicine University of British Columbia Vancouver Canada.
Bo Angela WanDepartment of Medicine University of British Columbia Vancouver Canada.
Amir KarinDepartment of Pathology and Laboratory Medicine University of British Columbia Vancouver Canada.
Lauren J LeeDepartment of Medicine Division of Hematology University of British Columbia Vancouver Canada.
Agnes Y Y LeeDepartment of Medicine Division of Hematology University of British Columbia Vancouver Canada.
Edward M ConwayDepartment of Medicine University of British Columbia Vancouver Canada.
Chieh Min Benjamin LaiDepartment of Medicine Division of Hematology University of British Columbia Vancouver Canada.ORCID https://orcid.org/0000-0002-4130-9413

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antiphospholipid syndrome (APS), cryoglobulinemia, and monoclonal gammopathies are variably accompanied by thrombotic complications. We describe a patient with recurrent skin microvascular thrombosis, APS, cryoglobulinemia, marginal zone lymphoma, and IgMκ monoclonal gammopathy, responsive to chemoimmunotherapy. The cryoglobulin fraction contained the IgMκ paraprotein, while antiphospholipid antibodies (aPL) were predominantly in the cryosupernatant. A retrospective analysis of aPL-positive patients in our institution showed that 8.1% co-expressed monoclonal gammopathy. These overlap patients had thrombotic complications and most had recurrences. Patients with multiple gammopathies of thrombotic significance may have several autoantibodies and constitute a high-risk group.

Indexed as

Antiphospholipid syndromecryoglobulinemiamonoclonal gammopathy of undetermined significancethrombosis

Identifiers

PMID39415921
PMCPMC11474285

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.