Evidence map›Paper›PMID 39415902›Full record

ArticleEJHaem2024

Real-world outcomes of patients with relapsed/refractory large B-cell lymphoma receiving second-line therapy in England.

Christopher P Fox, William Townsend, John G Gribben, Tobias Menne, Nagesh Kalakonda, Paula Williams, Farah Toron, Emma Tyas, Miranda Cooper, Joshua Rickards and 1 more

Abstract read
In one paragraph

Article in EJHaem, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Christopher P FoxSchool of Medicine University of Nottingham Nottingham UK.ORCID https://orcid.org/0000-0002-6322-9254
William TownsendUniversity College London Hospitals NHS Foundation Trust London UK.ORCID https://orcid.org/0000-0003-3975-2448
John G GribbenBarts Cancer Institute Barts Health NHS Trust London UK.
Tobias MenneNewcastle upon Tyne Hospitals NHS Foundation Trust Newcastle upon Tyne UK.ORCID https://orcid.org/0000-0002-3289-2344
Nagesh KalakondaMolecular & Clinical Cancer Medicine University of Liverpool Liverpool UK.
Paula WilliamsBristol Myers Squibb Uxbridge UK.
Farah ToronBristol Myers Squibb Uxbridge UK.
Emma TyasLumanity Farnham UK.
Miranda CooperLumanity Farnham UK.
Joshua RickardsLumanity Farnham UK.
John RadfordManchester Academic Health Science Centre The Christie NHS Foundation Trust and University of Manchester Manchester UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autologous stem-cell transplantation (ASCT) is standard therapy for relapsed/refractory large B-cell lymphoma (R/R LBCL), but many patients are either ineligible or unable to receive it. This retrospective study characterized outcomes in R/R LBCL, delineated by eligibility for, and receipt of, ASCT. Median progression-free survival (PFS) and event-free survival (EFS) for patients undergoing ASCT were 35.2 and 31.6 months (overall survival [OS] not reached). Median PFS, EFS, and OS were 4.3, 4.3, and 6.9 months for ineligible patients, and 2.7, 2.6, and 9.4 months for those eligible for but unable to receive ASCT. This highlights an unmet need for alternative therapies in patients unable to receive ASCT.

Indexed as

ASCTLBCLoutcomesreal‐world evidence

Identifiers

PMID39415902
PMCPMC11474359

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.