Evidence map›Paper›PMID 39415635›Full record

ArticleBrain and behavior2024

Rehabilitation Response in Tremor- and Non-Tremor-Dominant Parkinson Disease: A Task-fMRI Study.

Keke Chen, Songjian Wang, Qiping Wen, Zhaohui Jin, Yixuan Wang, Detao Meng, Xin Yu, Mengyue Wang, Meng Lin, Youwei Li and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain and behavior, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Keke ChenParkinson Medical Center, Beijing Rehabilitation Hospital, Capital Medical University, Beijing, China.
Songjian WangBeijing Institute of Otolaryngology, Otolaryngology-Head and Neck Surgery, Key Laboratory of Otolaryngology Head and Neck Surgery (Capital Medical University), Ministry of Education, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Qiping WenRadiology Department, Beijing Rehabilitation Hospital, Capital Medical University, Beijing, China.
Zhaohui JinParkinson Medical Center, Beijing Rehabilitation Hospital, Capital Medical University, Beijing, China.
Yixuan WangParkinson Medical Center, Beijing Rehabilitation Hospital, Capital Medical University, Beijing, China.
Detao MengParkinson Medical Center, Beijing Rehabilitation Hospital, Capital Medical University, Beijing, China.
Xin YuSchool of Beijing Rehabilitation Medicine, Capital Medical University, Beijing, China.
Mengyue WangSchool of Biomedical Engineering, Key Laboratory of Fundamental Research on Biomechanics in Clinical Application, Capital Medical University, Beijing, China.
Meng LinSchool of Biomedical Engineering, Key Laboratory of Fundamental Research on Biomechanics in Clinical Application, Capital Medical University, Beijing, China.
Youwei LiRadiology Department, Beijing Rehabilitation Hospital, Capital Medical University, Beijing, China.
Chunlin LiSchool of Biomedical Engineering, Key Laboratory of Fundamental Research on Biomechanics in Clinical Application, Capital Medical University, Beijing, China.
Boyan FangParkinson Medical Center, Beijing Rehabilitation Hospital, Capital Medical University, Beijing, China.ORCID https://orcid.org/0000-0002-9935-433X

Funding

Beijing Shijingshan District Medical Key Discipline Research Program 2023002The Key Research and Development Program of the Ministry of Science and Technology of the People's Republic of China 2022YFC3602603The Science and Technology Development Fund of Beijing Rehabilitation Hospital, Capital Medical University 2019-015The Science and Technology Development Fund of Beijing Rehabilitation Hospital, Capital Medical University 2019R-006The Science and Technology Development Fund of Beijing Rehabilitation Hospital, Capital Medical University 2020-069The Science and Technology Development Fund of Beijing Rehabilitation Hospital, Capital Medical University 2023R-04
6 · The paper itself

Abstract

backgroundTremor-dominant (TD) and nontremor-dominant (NTD) Parkinson's disease (PD) showed different responses to rehabilitation. However, the neural mechanism behind this remains unclear.

methodsThis cohort study explores changes in motor function, brain activation, and functional connectivity following 2 weeks of rehabilitation in TD-PD and NTD-PD patients, respectively. A total of 11 TD-PD patients, 24 NTD-PD patients, and 21 age-matched healthy controls (HCs) were included. At baseline, all participants underwent functional magnetic resonance imaging (fMRI) while performing the foot tapping task. Motor symptoms, gait, balance, and task-based fMRI were then evaluated in patients before and after rehabilitation.

resultsCompared to HCs, TD-PD patients showed increased activity in the left inferior frontal gyrus and the right insula, and NTD-PD patients showed increased activations in the left postcentral gyrus and decreased within-cerebellar connectivity at baseline. Rehabilitation improved motor function in PD patients regardless of motor subtype. TD-PD patients showed increased recruitments of the sensorimotor cortex and the bilateral thalamus after rehabilitation, and NTD-PD patients showed increased cerebellar activation and within-cerebellar connectivity that was associated with better motor performance.

conclusionsThis study demonstrated that rehabilitation-induced brain functional reorganization varied by motor subtypes in PD, which may have important implications for making individualized rehabilitation programs.

trial registrationClinicalTrials.gov identifier: ChiCTR1900020771.

Indexed as

Magnetic Resonance ImagingParkinson DiseaseTremorAgedBrainCase-Control StudiesCerebellumCohort StudiesFemaleHumansMaleMiddle AgedNeurological RehabilitationSensorimotor CortexThalamusbrain activationfMRIfunctional connectivitymotor subtypesParkinson's diseaserehabilitation

Identifiers

PMID39415635
PMCPMC11483598

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.