ArticleImmunity & ageing : I & A2024
Association between serum IgM and all-cause mortality risk in Chinese centenarians: a prospective cohort study.
Article in Immunity & ageing : I & A, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Low serum complement C3 levels are associated with all-cause mortality in Chinese centenarians: a prospective cohort study.Frontiers in immunology · 2026Article
- Association between the uric acid-to-albumin ratio and risk of all-cause mortality in centenarians: a prospective cohort study.Frontiers in nutrition · 2026Article
- Multiorgan transcriptomics in mice identifies immunoglobulin heavy constant mu (Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Associations of serum total light chain kappa and lambda levels with all-cause mortality in Chinese centenarians.Immunity & ageing : I & A · 2025Article
- Immunoglobulin: unraveling its complex web in aging.Frontiers in immunology · 2025Review
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Authors and funding
22 authors.
Funding
Abstract
backgroundWe investigated the associations between IgM, IgG, IgA, and IgE levels and all-cause mortality risk in Chinese centenarians.
methodsAll participants were from the China Hainan Centenarian Cohort Study. Eligible participants were divided into quartiles based on their IgM, IgG, IgA, and IgE levels. We used restricted cubic spline analyses, Cox regression analyses, and Kaplan-Meier survival curves to analyze associations between IgM, IgG, IgA, and IgE and all-cause mortality risk.
resultsA total of 906 centenarian participants were included in this study (81.2% female; median age, 102 years). During a median follow-up of 30.1 months, 838 (92.5%) participants died. Restricted cubic spline analysis revealed a nonlinear relationship ("L" type) between serum IgM level and all-cause mortality. Compared with the higher three quartiles of serum IgM level, the lowest quartile was associated with a higher risk of death (Q1 versus Q2-Q4: HR, 1.365; 95% CI, 1.166-1.598; P < 0.001). Among individuals for whom IgM < 0.708 g/L (Q1), the risk of all-cause mortality was 36.5% higher. Kaplan-Meier analyses showed that centenarians with lower serum IgM levels had significantly shorter median survival time (Q1 versus Q2-Q4: 26 months versus 32 months, log-rank P = 0.001).
conclusionSerum IgM levels in centenarians significantly correlated with the risk of death, suggesting that they are suitable for predicting the overall risk of death in centenarians and can be used as an independent predictor of death.
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