ArticleMolecular brain2024
Theta-gamma-coupling as predictor of working memory performance in young and elderly healthy people.
Article in Molecular brain, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- The Effects of High-Definition Transcranial Alternating Current Stimulation (HD-tACS) on Dual-Task Performance and Upper-Limb Multi-Joint Motor Control.Life (Basel, Switzerland) · 2026Article
- Hippocampal skill memory expansion drives online performance dynamics during skill learning.Cell reports · 2026Article
- Review
- Skill Memory Expansion Shapes Micro-Scale Dynamics of Skill Learning.bioRxiv : the preprint server for biology · 2026Article
- Neurophysiological Effects of a Digital Therapeutic for Attention-deficit/Hyperactivity Disorder: A Quantitative Electroencephalography Analysis of Theta-Gamma Coupling.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2026Article
- Regulation of Synaptic Plasticity and Adaptive Convergence Under Rhythmic Stimulation of an In Vitro Hippocampal Neuronal Network of Cultured Cells.Biosensors · 2026Article
- Designing Neural Dynamics: From Digital Twin Modeling to Regeneration.International journal of molecular sciences · 2025Review
- Review
- Repetitive Gamma-tACS Improves the Reaction Times of Healthy Young Adults in a Visuospatial Working Memory Task: A Randomized Study.Brain sciences · 2025Article
- Lateral hypothalamic area high-frequency deep brain stimulation rescues memory decline in aged rat: behavioral, molecular, and electrophysiological study.Pflugers Archiv : European journal of physiology · 2025Article
- Artificial Intelligence and Neuroscience: Transformative Synergies in Brain Research and Clinical Applications.Journal of clinical medicine · 2025Review
- Different frequencies of human scalp-recorded theta activity may index integration of activity in distinct recurrent cortico-subcortical mnemonic networks.Frontiers in behavioral neuroscience · 2025Review
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Authors and funding
5 authors.
Funding
Abstract
The relationship between working memory (WM) and neuronal oscillations can be studied in detail using brain stimulation techniques, which provide a method for modulating these oscillations and thus influencing WM. The endogenous coupling between the amplitude of gamma oscillations and the phase of theta oscillations is crucial for cognitive control. Theta/gamma peak-coupled transcranial alternating current stimulation (TGCp-tACS) can modulate this coupling and thus influence WM performance. This study investigated the effects of TGCp-tACS on WM in older adults and compared their responses with those of younger participants from our previous work who underwent the same experimental design. Twenty-eight older subjects underwent both TGCp-tACS and sham stimulation sessions at least 72 h apart. Resting-state electroencephalography (EEG) was recorded before and after the interventions, and a WM task battery with five different WM tasks was performed during the interventions to assess various WM components. Outcomes measured included WM task performance (e.g., accuracy, reaction time (RT)) and changes in power spectral density (PSD) in different frequency bands. TGCp-tACS significantly decreased accuracy and RT on the 10- and 14-point Sternberg tasks and increased RT on the Digit Symbol Substitution Test in older adults. In contrast, younger participants showed a significant increase in accuracy only on the 14-item Sternberg task. Electrophysiological analysis revealed a decrease in delta and theta PSD and an increase in high gamma PSD in both younger and older participants after verum stimulation. In conclusion, theta-gamma coupling is essential for WM and modulation of this coupling affects WM performance. The effects of TGCp-tACS on WM vary with age due to natural brain changes. To better support older adults, the study suggests several strategies to improve cognitive function, including: Adjusting stimulation parameters, applying stimulation to two sites, conducting multiple sessions, and using brain imaging techniques for precise targeting.
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