Evidence map›Paper›PMID 39415187›Full record

ArticleLipids in health and disease2024

Increased thyroid hormone sensitivity is correlated with visceral obesity in patients with type 2 diabetes.

Lu Yu, Yujia Liu, Yingxuan Wang, Gang Wang, Xianchao Xiao, Huan Wang, Hanyu Wang, Hui Sun, Guixia Wang

Abstract read
In one paragraph

Article in Lipids in health and disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lu YuDepartment of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun, 130021, China.
Yujia LiuDepartment of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun, 130021, China.
Yingxuan WangDepartment of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun, 130021, China.
Gang WangDepartment of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun, 130021, China.
Xianchao XiaoDepartment of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun, 130021, China.
Huan WangDepartment of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun, 130021, China.
Hanyu WangDepartment of Endocrinology and Metabolism, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430000, China.
Hui SunDepartment of Endocrinology and Metabolism, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430000, China. sunny68@hust.edu.cn.ORCID http://orcid.org/0000-0002-7684-4715
Guixia WangDepartment of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun, 130021, China. gwang168@jlu.edu.cn.ORCID http://orcid.org/0000-0001-8107-616X

Funding

Bethune Charitable Foundation Z04JKM2022E036National Natural Science Foundation of China No. 82270832the Department of Science and Technology of Jilin Province 20210303001SF
6 · The paper itself

Abstract

objectiveThe study aimed to assess whether thyroid hormone (TH) sensitivity is related to visceral fat area (VFA) and visceral obesity in euthyroid subjects with type 2 diabetes (T2D).

methods750 euthyroid patients with T2D were enrolled. A VFA of 80 cm

resultsThe subjects had a mean age of 51.5 ± 11.1 years, and 540 (72.0%) of them were men. In multivariable regression analyses, there was a positive correlation of FT3/FT4 tertile with visceral obesity, after full adjustment for confounding variables (P < 0.05). The middle and highest FT3/FT4 tertiles were correlated with a 134% [95% CI (1.24, 4.44)] and 98% [95% CI (1.04, 3.78)] higher prevalence of visceral obesity than the lowest tertile, respectively. Conversely, elevated TFQI levels were linked to a decreased prevalence of visceral obesity. Stratified analysis revealed that these associations were particularly pronounced in participants who are neither overweight nor obese and those aged less than 60 years (all P < 0.05).

conclusionsHigher TH sensitivity is correlated with visceral obesity and elevated VFA in euthyroid patients with T2D, particularly among those younger than 60 years and individuals who are neither overweight nor obese.

Indexed as

Diabetes Mellitus, Type 2Obesity, AbdominalThyroxineTriiodothyronineAdultFemaleHumansIntra-Abdominal FatMaleMiddle AgedThyroid HormonesThyrotropinThyroid HormonesThyrotropinThyroxineTriiodothyronineFree triiodothyronine to free thyroxineSensitivity to thyroid hormonesThyroid feedback quantile-based indexVisceral fat areaVisceral obesity

Identifiers

PMID39415187
PMCPMC11481250

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.