Evidence map›Paper›PMID 39415172›Full record

ArticleBMC pediatrics2024

Chronic active Epstein-Barr Virus infection in a teenage girl with suspect autoimmune Hepatitis.

Wen-Yu Tseng, Shiu-Feng Huang, Chao-Yi Wu, Shih-Hsiang Chen, Chien-Chang Chen

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pediatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Wen-Yu TsengDepartment of Pediatrics, Dali Branch, Jen Ai Hospital, No. 483, Dongrong Rd., Dali Dist, Taichung City, 412, Taiwan.
Shiu-Feng HuangDepartment of Pathology, Linkou Branch, Chang Gung Memorial Hospital, No. 5, Fuxing St., Guishan Dist, Taoyuan City, 333, Taiwan.
Chao-Yi WuDivision of Pediatric Allergy, Asthma, and Rheumatology, Department of Pediatrics, Linkou Branch, Chang Gung Children's Medical Center, Chang Gung Memorial Hospital, No. 5, Fuxing St., Guishan Dist, Taoyuan City, 333, Taiwan.
Shih-Hsiang ChenDivisions of Pediatric Hematology and Oncology, Department of Pediatrics, Linkou Branch, Chang Gung Children's Medical Center, Chang Gung Memorial Hospital, No. 5, Fuxing St., Guishan Dist, Taoyuan City, 333, Taiwan.
Chien-Chang ChenDivision of Pediatric Gastroenterology, Department of Pediatrics, Linkou Branch, Chang Gung Children's Medical Center, Chang Gung Memorial Hospital, No. 5, Fuxing St., Guishan Dist, Taoyuan City, 33305, Taiwan. cgj2841@cgmh.org.tw.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe pathogenesis of chronic active Epstein-Barr virus (EBV) disease (CAEBV) is complex, involving infection, inflammation, and in some cases malignancy. EBV reactivates in some patients, who develop a chronic disease with infectious mononucleosis-like symptoms. On occasion, it might be confused with autoimmune hepatitis (AIH), based on the similar symptoms and elevated liver enzymes. We aimed to describe a similar case to remind reader of this disease. CASE PRESENTATION: A 14-year-old girl was diagnosed with AIH based on biopsy and biomarker findings 1 year prior to admission and initially presented with elevated liver enzymes, portal hypertension, and parenchymal liver disease. Despite steroid administration, her condition fluctuated, and she was admitted to the hospital several times. She underwent a renal biopsy because of massive ascites, hypoalbuminemia, and increased renal echogenicity. An evaluation for impaired liver function showed positivity for EBV IgM, IgG, and early antigen (EBEA) antibodies. A PCR-based assay showed 5265 copies/mL of EBV DNA in peripheral blood. Epstein-Barr encoding region (EBER) in situ hybridization revealed abundant positive cells. Immunohistochemistry for CD56 also showed abundant positive cells, and CAEBV was diagnosed on this basis. Chemotherapy, hematopoietic stem cell transplantation (HSCT), and liver transplantation were proposed but her family refused.

conclusionsCAEBV should be considered when diagnosing AIH or in cases of treatment-refractory AIH.

Indexed as

Epstein-Barr Virus InfectionsHepatitis, AutoimmuneAdolescentChronic DiseaseDiagnosis, DifferentialFemaleHumansAutoimmune hepatitisChronic active Epstein–Barr virus infectionGirlTeen age

Identifiers

PMID39415172
PMCPMC11481802

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.