ArticleRespiratory research2024
A genome-wide association study of adults with community-acquired pneumonia.
Article in Respiratory research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Exploring imputation performance of phenotype-associated SNPs for forensic prediction models.Scientific reports · 2026Article
- Identifying sepsis susceptibility genes in post-surgical patients using an artificial intelligence approach.Frontiers in medicine · 2025Article
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Authors and funding
22 authors.
Funding
Abstract
backgroundCommunity-acquired pneumonia (CAP) is associated with high morbidity and hospitalization rate. In infectious diseases, host genetics plays a critical role in susceptibility and immune response, and the immune pathways involved are highly dependent on the microorganism and its route of infection. Here we aimed to identify genetic risk loci for CAP using a case-control genome-wide association study (GWAS).
methodsWe performed a GWAS on 3,765 Spanish individuals, including 257 adult patients hospitalized with CAP and 3,508 population controls. Pneumococcal CAP was documented in 30% of patients; the remaining 70% were selected among patients with unidentified microbiological etiology. We tested 7,6 million imputed genotypes using logistic regressions. UK Biobank GWAS of bacterial pneumonia were used for results validation. Subsequently, we prioritized genes and likely causal variants based on Bayesian fine mapping and functional evidence. Imputation and association of classical HLA alleles and amino acids were also conducted.
resultsSix independent sentinel variants reached the genome-wide significance (p < 5 × 10
conclusionsWe completed a GWAS of CAP and identified four novel risk loci involved in CAP susceptibility.
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