Evidence map›Paper›PMID 39415090›Full record

ArticleBMC infectious diseases2024

An epidemiological and spatiotemporal analysis of visceral leishmaniasis in West Pokot, Kenya, between 2018 and 2022.

Norbert J van Dijk, Sherif Amer, Daniel Mwiti, Henk D F H Schallig, Ellen-Wien Augustijn

Registry-linked trialAbstract read
In one paragraph

Article in BMC infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07506967 (Early Detection and Management of SKIN-related negleCted Tropical Diseases Using Artificial Intelligence in Sub-saharan afRica), which is not on this map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07506967 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Early Detection and Management of SKIN-related negleCted Tropical Diseases Using Artificial Intelligence in Sub-saharan afRica (SkincAIr)

TypeinterventionalSponsorKenya Medical Research InstituteRan2026 to 2030Enrolled2,420ConditionsSkin and Connective Tissue Diseases, Neglected Tropical Diseases, Leprosy, Buruli UlcerArmsA mobile app with AI functionality for diagnosing skin-related NTDs
3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Norbert J van DijkDepartment of Medical Microbiology and Infection Prevention, Laboratory for Experimental Parasitology, Amsterdam University Medical Centre, Meibergdreef 9, Amsterdam, 1105 AZ, The Netherlands. n.j.vandijk@amsterdamumc.nl.
Sherif AmerFaculty of Geo-Information Science and Earth Observation (ITC), Department of Urban and Regional Planning and Geo-Information Management (PGM), University of Twente, Hallenweg 8, Enschede, 7522 NH, The Netherlands.
Daniel MwitiDivision of Vector-Borne and Neglected Tropical Diseases, Kenya Ministry of Health, Nairobi, Kenya.
Henk D F H SchalligDepartment of Medical Microbiology and Infection Prevention, Laboratory for Experimental Parasitology, Amsterdam University Medical Centre, Meibergdreef 9, Amsterdam, 1105 AZ, The Netherlands.
Ellen-Wien AugustijnFaculty of Geo-Information Science and Earth Observation (ITC), Department of Geo-information Processing (GIP), University of Twente, Hallenweg 8, Enschede, 7522 NH, The Netherlands.

Funding

Amsterdam Institute for Immunology and Infectious Diseases Work Visit Grant 2022
6 · The paper itself

Abstract

backgroundVisceral leishmaniasis (VL) remains a significant public health concern in West Pokot County, Kenya, where a large outbreak between 2020 and 2022 emphasised the need for improved VL control strategies. However, these measures are partially hampered by limited insight into the geographical distribution of cases and localised outbreaks of the disease. This study aimed to describe the epidemiology and spatiotemporal patterns of VL in West Pokot between 2018 and 2022, in order to map the spread of VL transmission and identify regions that should be prioritised for control interventions.

methodsVL patient demographics and village of residence were retrieved from admission records of Kacheliba Sub-County Hospital in West Pokot, Kenya. The temporal trend in VL admissions between 2018 and 2022 was analysed using seasonal decomposition analysis. To describe the spatial distribution of VL cases, geographic coordinates of villages of residence were collected from pre-established databases, and VL incidence was mapped at the sub-location level. Hotspot analysis was performed per study year to identify villages with high VL incidence, and scan statistics were applied to detect spatiotemporal clusters of VL cases during the study period.

resultsA total of 1948 VL patients were reported between 2018 and 2022. The annual number of cases increased from 245 in 2019 to 598 in 2022, and VL admissions were generally higher at the start of the wet seasons. 70% of the VL cases could be georeferenced, and mapping of VL incidence revealed high case rates in the east of West Pokot during the complete study period. The eastern villages Lotongot and Chepaywat were marked as VL hotspots at a 99% confidence level in all study years. In addition, five significant spatiotemporal clusters were detected in the east and north, suggestive of local VL outbreaks in these regions.

conclusionsThe increase in VL hospital admissions during the study period stresses the need for enhanced VL control and outbreak mitigation in West Pokot. These control measures should be focused on the hotspot regions in the east of the county.

Indexed as

Leishmaniasis, VisceralSpatio-Temporal AnalysisAdolescentAdultChildChild, PreschoolDisease OutbreaksFemaleHospitalizationHumansIncidenceInfantKenyaMaleMiddle AgedSeasonsKenyaLeishmania donovaniSpatiotemporal analysisVisceral leishmaniasis

Identifiers

PMID39415090
PMCPMC11484382

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Registered trials

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