Evidence map›Paper›PMID 39415084›Full record

ArticleBMC genomics2024

Clusterin from endometrial glands plays a critical role in decidualization via Trem2.

Sitong Yao, Yingni Chen, Rui Cao, Lin Lu, Jingsi Yang, Wei Lei, Yugu Li, Xiaohuan Liang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC genomics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sitong YaoCollege of Veterinary Medicine, South China Agricultural University, 483 Wushan Road, Guangzhou, 510642, Guangdong, China.
Yingni ChenCollege of Veterinary Medicine, South China Agricultural University, 483 Wushan Road, Guangzhou, 510642, Guangdong, China.
Rui CaoCollege of Veterinary Medicine, South China Agricultural University, 483 Wushan Road, Guangzhou, 510642, Guangdong, China.
Lin LuCollege of Veterinary Medicine, South China Agricultural University, 483 Wushan Road, Guangzhou, 510642, Guangdong, China.
Jingsi YangDepartment of Cardiovascular Surgery of the First Affiliated Hospital & Institute for Cardiovascular Science, Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Protection, Suzhou Medical College, Soochow University, Suzhou, 215000, Jiangsu, China.
Wei LeiDepartment of Cardiovascular Surgery of the First Affiliated Hospital & Institute for Cardiovascular Science, Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Protection, Suzhou Medical College, Soochow University, Suzhou, 215000, Jiangsu, China. leiwei@suda.edu.cn.
Yugu LiCollege of Veterinary Medicine, South China Agricultural University, 483 Wushan Road, Guangzhou, 510642, Guangdong, China. liyugu@scau.edu.cn.
Xiaohuan LiangCollege of Veterinary Medicine, South China Agricultural University, 483 Wushan Road, Guangzhou, 510642, Guangdong, China. xhliang@scau.edu.cn.

Funding

Doublefirst-class discipline promotion project Grant 2023B10564003National Natural Science Foundation of China 81970223
6 · The paper itself

Abstract

backgroundDecidualization is a critical step in establishing pregnancy in mammals. Successful decidualization depends on intricate gland-stromal crosstalk. Clusterin (Clu) is a ubiquitously secreted protein in physiological fluids that is involved in numerous physiological functions. However, the role of Clu in decidualization is not fully understood.

resultsIn this study, we examined the expression pattern of Clu during early pregnancy in mice and explored its potential function in decidualization. Our results revealed that Clu was expressed in the uterine glands on Days 1-2 of early pregnancy and on Days 5-8 during decidualization after embryo implantation, as well as in glands at the interimplantation site. Additionally, ovariectomized mice exhibited significant upregulation of Clu expression in the uterine glands 3 h after in vivo estrogen injection. Trem2, a receptor for Clu, was detected in the decidual region of mice on Days 5-8 of early pregnancy, where it mediates Clu to regulate the decidual region. Furthermore, we observed that recombinant CLU protein increased the expression of the decidualization marker molecules insulin-like growth factor binding protein 1 (IGFBP1) and prolactin (PRL) in decidual cells. However, this upregulation was not observed when Trem2 expression was inhibited with siRNA.

conclusionsUterine gland-derived Clu, a new paracrine modulator, may participate in early pregnancy by influencing the decidualization process mediated by Trem2 in mice.

Indexed as

ClusterinDeciduaEndometriumMembrane GlycoproteinsReceptors, ImmunologicAnimalsEmbryo ImplantationFemaleMicePregnancyProlactinClu protein, mouseClusterinMembrane GlycoproteinsProlactinReceptors, ImmunologicTrem2 protein, mouseCluDecidualizationEarly pregnancyTrem2Uterine glands

Identifiers

PMID39415084
PMCPMC11481393

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.