Evidence map›Paper›PMID 39415038›Full record

Observational studyPediatric research2025

Utility of urinary NT-proBNP in congenital diaphragmatic hernia: a prospective pilot study.

Srirupa Hari Gopal, Kelly Frances Martinek, Candice Vacher, Judith Becker, Nidhy P Varghese, Betul Yilmaz Furtun, Joseph L Hagan, Sharada H Gowda, Mohan Pammi, Sridevi Devaraj and 1 more

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Pediatric research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Srirupa Hari GopalDivision of Neonatology, Department of Pediatrics, Baylor College of Medicine, Houston, USA. Srirupa.harigopal@gmail.com.
Kelly Frances MartinekDivision of Neonatology, Department of Pediatrics, Baylor College of Medicine, Houston, USA.
Candice VacherDivision of Pediatric Cardiology, Department of Pediatrics, Baylor College of Medicine, Houston, USA.
Judith BeckerDivision of Pediatric Cardiology, Department of Pediatrics, Baylor College of Medicine, Houston, USA.
Nidhy P VargheseDivision of Pediatric Pulmonology/Pulmonary Hypertension, Department of Pediatrics, Baylor College of Medicine, Houston, USA.
Betul Yilmaz FurtunDivision of Pediatric Cardiology, Department of Pediatrics, Baylor College of Medicine, Houston, USA.
Joseph L HaganDivision of Neonatology, Department of Pediatrics, Baylor College of Medicine, Houston, USA.
Sharada H GowdaDivision of Neonatology, Department of Pediatrics, Baylor College of Medicine, Houston, USA.
Mohan PammiDivision of Neonatology, Department of Pediatrics, Baylor College of Medicine, Houston, USA.
Sridevi DevarajDepartment of Pathology, Baylor College of Medicine, Houston, USA.
Caraciolo J FernandesDivision of Neonatology, Department of Pediatrics, Baylor College of Medicine, Houston, USA.

Funding

Neonatal-Perinatal Medicine at Baylor College of Medicine
6 · The paper itself

Abstract

backgroundEchocardiography is the reference standard for diagnosing pulmonary hypertension (PH) and cardiac dysfunction (CD) in congenital diaphragmatic hernia (CDH). The use of an adjunct non-invasive biomarker would be invaluable. Plasma N-terminal brain Natriuretic Peptide (NT-proBNP) has been evaluated as a biomarker in CDH. Our objective was to investigate the utility of urinary NT-proBNP as an adjunct biomarker in CDH.

methodsProspective observational study of neonates with CDH. Urinary NT-proBNP and its ratio to urinary creatinine (UNBCR) were analyzed at 24 h of life (HOL). Spearman's correlation was used to quantify the association between the urinary NT-proBNP with corresponding plasma concentrations. Logistic regression and receiver operating characteristic (ROC) curve analyses were used to examine urinary NT-proBNP and UNBCR's association with need for ECMO. The Kruskal-Wallis test was used to compare urinary NT-proBNP concentrations with echocardiography parameters of PH and CD.

resultsUrinary NT-proBNP and UNBCR positively correlated with plasma concentrations. Patients with high right ventricular (RV) pressures had higher urinary NT-proBNP concentrations. Both urinary NT-proBNP and UNBCR concentrations increased with worsening left and right ventricular dysfunction on first postnatal echocardiogram.

conclusionWe report the feasibility of urinary NT-proBNP as a non-invasive biomarker to assess PH and CD in CDH. IMPACT STATEMENT: Non-invasive biomarkers are an important area of research in neonates as they have the potential to decrease the need for blood sampling, which may cause pain, stress, and induce iatrogenic anemia. Use of non-invasive biomarkers could be especially useful in congenital diaphragmatic hernia (CDH) who may need Extra-Corporeal Life Support (ECLS) for their management. We evaluated the potential utility of the urinary NT-proBNP in CDH. Plasma NT-proBNP has been studied in neonates with CDH; however, urinary NT-proBNP has not been explored, making this the first study to examine its potential as a biomarker.

Indexed as

Hernias, Diaphragmatic, CongenitalNatriuretic Peptide, BrainPeptide FragmentsBiomarkersCreatinineEchocardiographyFemaleHumansHypertension, PulmonaryInfant, NewbornMalePilot ProjectsProspective StudiesROC CurveBiomarkersCreatinineNatriuretic Peptide, BrainPeptide Fragmentspro-brain natriuretic peptide (1-76)

Identifiers

PMID39415038

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.