Evidence map›Paper›PMID 39415036›Full record

ArticlePediatric research2025

Visual pathways functioning in healthy pre-term adolescents: Sex but not gestational age effect.

Matilde Taddei, Francesca Tinelli, Flavia Faccio, Daria Riva, Sara Bulgheroni

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Article in Pediatric research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Matilde TaddeiPediatric Neuroscience Department Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy.
Francesca TinelliDepartment of Developmental Neuroscience IRCCS Fondazione Stella Maris, Pisa, Italy.
Flavia FaccioPediatric Neuroscience Department Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy.
Daria RivaPediatric Neuroscience Department Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy.
Sara BulgheroniPediatric Neuroscience Department Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy. sara.bulgheroni@istituto-besta.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVisuo-spatial and visuo-perceptual functioning is widely studied in preterm child and is strongly sex-specific. However, little to no data is available regarding male-female differences in preterm children and adolescents and about the interaction effect between sex and preterm birth.

methodsWe studied 30 adolescents born preterm with normal cognitive and clinical neurological outcomes and 34 age-matched controls to investigate the interaction between levels of prematurity and sex in predicting the outcome of visual pathways functioning and to explore the relation between psychophysiological perceptive processing and neuropsychological performance.

resultsIn the presence of prematurity, a greater female vulnerability in central visuo-cognitive processing (Form Coherence Task), but not in neuropsychological accuracy (Street Completion Test and Visual Object and Space Perception battery), seems to be more evident. Moreover, the psychophysical threshold is correlated to neuropsychological accuracy only in preterm females and not in males.

conclusionThese results support the idea that the male vulnerability in cognitive functioning described in prematurity-related developmental conditions is negligible during school age in children-adolescents with normal cognitive and clinical neurological outcomes. IMPACT: Visuo-perceptual functioning is widely studied in prematurity. However, few data are available about the interaction effect between sex and preterm birth in predicting visuo-perceptual functioning. We evidenced that in females born preterm with preserved cognitive abilities, the efficiency of the psychophysical visuo-perceptual threshold is reduced, but not related to the neuropsychological performance. Females may implement compensation strategies to achieve good performance regardless of the perceptual threshold. The present study addresses an important gap in literature, suggesting possible sex-specific outcomes in visuo-perceptual ability among preterm children and adolescents with normal intelligence and neurological outcomes.

Indexed as

Gestational AgeInfant, PrematureVisual PathwaysVisual PerceptionAdolescentCase-Control StudiesChildCognitionFemaleHumansInfant, NewbornMaleNeuropsychological TestsPremature BirthSex Factors

Identifiers

PMID39415036
PMCPMC12279541

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.