ArticleNature genetics2024
A regulatory network controlling developmental boundaries and meristem fates contributed to maize domestication.
Article in Nature genetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- The OsSPL-SNB complex orchestrates the reproductive transition through tillering suppression in rice.aBIOTECH · 2026Article
- Hybrid origin and phenotype evolution of the modern maize.Journal of integrative plant biology · 2026Review
- Achieving High-Density and Stress-Resilient Maize Breeding Via Germplasm Innovation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Global genetic dissection of maize-teosinte divergence reveals EL3-2 as a pleiotropic domestication regulator.Genome biology · 2026Article
- Article
- Mechanism of tobacco hairy root development and functional study of the HSF gene family based on comparative transcriptomics.BMC plant biology · 2026Article
- Plant domestication revisited: Genomic insights into origins, mechanisms, and convergent evolution.iScience · 2026Review
- Decades' progress and prospects on maize functional genomics and molecular breeding.Science China. Life sciences · 2025Review
- Spatial and single-cell expression analyses reveal complex expression domains in early wheat spike development.Genome biology · 2025Article
- Transcriptomic and metabolic changes during tassel branching development in maize.BMC plant biology · 2025Article
- Genome-Wide Association Study and Candidate Gene Mining of Husk Number Trait in Maize.International journal of molecular sciences · 2025Article
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Authors and funding
8 authors.
Funding
Abstract
During domestication, early farmers selected different vegetative and reproductive traits, but identifying the causative loci has been hampered by their epistasis and functional redundancy. Using chromatin immunoprecipitation sequencing combined with genome-wide association analysis, we uncovered a developmental regulator that controls both types of trait while acting upstream of multiple domestication loci. tasselsheath4 (tsh4) is a new maize domestication gene that establishes developmental boundaries and specifies meristem fates despite not being expressed within them. TSH4 accomplishes this by using a double-negative feedback loop that targets and represses the very same microRNAs that negatively regulate it. TSH4 functions redundantly with a pair of homologs to positively regulate a suite of domestication loci while specifying the meristem that doubled seed yield in modern maize. TSH4 has a critical role in yield gain and helped generate ideal crop plant architecture, thus explaining why it was a major domestication target.
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