Evidence map›Paper›PMID 39415022›Full record

ArticleNature2024

A bacterial immunity protein directly senses two disparate phage proteins.

Tong Zhang, Albinas Cepauskas, Anastasiia Nadieina, Aurelien Thureau, Kyo Coppieters 't Wallant, Chloé Martens, Daniel C Lim, Abel Garcia-Pino, Michael T Laub

Abstract read
In one paragraph

Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Article
  2. How bacterial immune systems sense phage infection.Nature reviews. Microbiology · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tong ZhangDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0003-4745-8580
Albinas CepauskasCellular and Molecular Microbiology, Faculté des Sciences, Université Libre de Bruxelles (ULB), Brussels, Belgium.ORCID 0000-0002-4601-0015
Anastasiia NadieinaCellular and Molecular Microbiology, Faculté des Sciences, Université Libre de Bruxelles (ULB), Brussels, Belgium.
Aurelien ThureauCentre for Structural Biology and Bioinformatics, Université Libre de Bruxelles (ULB), Brussels, Belgium.
Kyo Coppieters 't WallantSynchrotron SOLEIL, Gif sur Yvette, France.ORCID 0000-0003-2358-999X
Chloé MartensSynchrotron SOLEIL, Gif sur Yvette, France.
Daniel C LimDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0002-8861-4837
Abel Garcia-PinoCellular and Molecular Microbiology, Faculté des Sciences, Université Libre de Bruxelles (ULB), Brussels, Belgium. abel.garcia.pino@ulb.be.ORCID 0000-0002-0634-0300
Michael T LaubDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA. laub@mit.edu.ORCID 0000-0002-8288-7607

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Eukaryotic innate immune systems use pattern recognition receptors to sense infection by detecting pathogen-associated molecular patterns, which then triggers an immune response. Bacteria have similarly evolved immunity proteins that sense certain components of their viral predators, known as bacteriophages

Indexed as

BacteriophagesEscherichia coliEscherichia coli ProteinsViral ProteinsEvolution, MolecularImmunity, InnateModels, MolecularProtein BindingProtein DomainsReceptors, Pattern RecognitionEscherichia coli ProteinsReceptors, Pattern RecognitionViral Proteins

Identifiers

PMID39415022
PMCPMC11578894

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.