ArticleNature2024
Spatial proteomics identifies JAKi as treatment for a lethal skin disease.
Abstract readClinical Study
In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed, 2 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
78 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Systemic Therapy for Paediatric Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A Systematic Review of Current Evidence and Limitations.Journal of paediatrics and child health · 2026Pooled it
- Mass spectrometry-based human spatial omics: fundamentals, innovations, and applications.Journal of biomedical science · 2026Pooled it
- Protein-Ratio Rheostats: Integrating Stoichiometry, Abundance, and Binding Affinity in Cellular Function.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026Review
- Emerging technologies in the spatial proteomics landscape.Analytical and bioanalytical chemistry · 2026Review
- Probing the proteome at cellular scale.Nature · 2026Article
- Development of Multidisciplinary Consensus-Informed Guidance for the Management of Paediatric Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Among Clinicians From Australasian Tertiary Referral Hospitals.Journal of paediatrics and child health · 2026Review
- Biologics and Small Molecule Inhibitors: Novel Therapeutic Strategies for Cutaneous Adverse Drug Reactions.Drugs · 2026Review
- Proteomic investigation of signaling dynamics: from static maps to network rewiring.Bioscience reports · 2026Review
- Cardiac immunity and heart repair: Mechanism, challenge, and future direction.Chinese medical journal · 2026Review
- [Gemcitabine-induced toxic epidermal necrolysis in a patient with mycosis fungoides].Dermatologie (Heidelberg, Germany) · 2026Article
- New Insights Into Immunomodulatory Strategies for Drug Hypersensitivity Reactions: An EAACI Task Force Report.Clinical and translational allergy · 2026Review
- Proteomics and human microchips identify Thrombospondin-1 as a potential biomarker for calciphylaxis stem cell therapy.iScience · 2026Article
- Consensus statement on mass spectrometry-based proteomic analysis of cardiac tissue.Nature cardiovascular research · 2026Article
- Filter-aided expansion proteomics for the spatial analysis of single cells and organelles in FFPE tissue samples.Nature protocols · 2026Review
- Potential of Clinical Care-Collected Gut Biopsies for Advancing Personalised Medicine in Inflammatory Bowel Disease.United European gastroenterology journal · 2026Review
- Pro-regenerative fingerprints identified in a sub-population of adult mouse cardiomyocytes by integrative single-cell proteomics.Genome biology · 2026Article
- Early Proteomic Alterations in Non-segmental Vitiligo Skin Following Treatment with Topical Tacrolimus.Dermatology and therapy · 2026Article
- Just the facts: diagnosis and management of Stevens-Johnson syndrome/toxic epidermal necrolysis.CJEM · 2026Article
- JAK inhibition may prevent drug hypersensitivity reactions.JCI insight · 2026Article
- Single-Cell and Spatial Omics: Methods and Applications.MedComm · 2026Review
18 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
34 authors.
Thierry M NordmannDepartment of Proteomics and Signal Transduction; Max Planck Institute of Biochemistry, Martinsried, Germany. nordmann@biochem.mpg.de.ORCID 0000-0002-3702-815X
Holly AndertonInflammation division, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.ORCID 0000-0003-3913-9686
Akito HasegawaDivision of Dermatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
Lisa SchweizerDepartment of Proteomics and Signal Transduction; Max Planck Institute of Biochemistry, Martinsried, Germany.
Peng ZhangDepartment of Dermatology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Pia-Charlotte StadlerDepartment of Proteomics and Signal Transduction; Max Planck Institute of Biochemistry, Martinsried, Germany.
Ankit SinhaDepartment of Proteomics and Signal Transduction; Max Planck Institute of Biochemistry, Martinsried, Germany.
Andreas MetousisDepartment of Proteomics and Signal Transduction; Max Planck Institute of Biochemistry, Martinsried, Germany.ORCID 0000-0002-1043-6591
Florian A RosenbergerDepartment of Proteomics and Signal Transduction; Max Planck Institute of Biochemistry, Martinsried, Germany.ORCID 0000-0003-4604-6170
Maximilian ZwiebelDepartment of Proteomics and Signal Transduction; Max Planck Institute of Biochemistry, Martinsried, Germany.ORCID 0000-0002-7005-5619
Takashi K SatohDepartment of Dermatology and Allergy, University Hospital, Ludwig Maximilian University (LMU) Munich, Munich, Germany.ORCID 0000-0002-6064-9253
Florian AnzengruberDepartment of Dermatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Maximilian T StraussProteomics Program, Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Faculty of Health and Medical Sciences, Copenhagen, Denmark.
Maria C TanzerInflammation division, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
Yuki SaitoDivision of Dermatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
Ting GongDepartment of Dermatology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Marvin ThielertDepartment of Proteomics and Signal Transduction; Max Planck Institute of Biochemistry, Martinsried, Germany.ORCID 0000-0003-3639-2221
Haruna KimuraDivision of Dermatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.ORCID 0000-0002-5389-3442
Natasha SilkeInflammation division, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
Edwin H RodriguezDepartment of Proteomics and Signal Transduction; Max Planck Institute of Biochemistry, Martinsried, Germany.
Gaetana RestivoDepartment of Dermatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.ORCID 0000-0003-4364-2364
Hong Ha NguyenDivision of Dermatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
Annette GrossImmunoregulation Research Group, Max Planck Institute of Biochemistry, Martinsried, Germany.
Laurence FeldmeyerDepartment of Dermatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.ORCID 0000-0002-4858-5525
Lukas JoergDivision of Allergology and Clinical Immunology, Department of Pneumology, Allergology and Clinical Immunology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Mitchell P LevesqueDepartment of Dermatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.ORCID 0000-0001-5902-9420
Peter J MurrayImmunoregulation Research Group, Max Planck Institute of Biochemistry, Martinsried, Germany.ORCID 0000-0001-6329-9802
Saskia Ingen-Housz-OroDermatology Department, AP-HP, Henri Mondor Hospital, Créteil, France.
Andreas MundProteomics Program, Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Faculty of Health and Medical Sciences, Copenhagen, Denmark.ORCID 0000-0002-7843-5341
Riichiro AbeDivision of Dermatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
John SilkeInflammation division, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.ORCID 0000-0002-7611-5774
Chao JiDepartment of Dermatology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China. jichaofy@fjmu.edu.cn.ORCID 0000-0002-2282-3505
Lars E FrenchDepartment of Dermatology and Allergy, University Hospital, Ludwig Maximilian University (LMU) Munich, Munich, Germany. Lars.French@med.uni-muenchen.de.ORCID 0000-0002-4629-1486
Matthias MannDepartment of Proteomics and Signal Transduction; Max Planck Institute of Biochemistry, Martinsried, Germany. mmann@biochem.mpg.de.ORCID 0000-0003-1292-4799
Funding
No grant is acknowledged in the PubMed record.
Abstract
Toxic epidermal necrolysis (TEN) is a fatal drug-induced skin reaction triggered by common medications and is an emerging public health issue
Indexed as
Janus Kinase 1Janus Kinase InhibitorsKeratinocytesProteomicsStevens-Johnson SyndromeAdministration, OralAnimalsAzetidinesBiopsyDisease Models, AnimalFemaleHeterocyclic Compounds, 3-RingHumansInterferon-gammaInterferon Type IMaleabrocitinibAzetidinesbaricitinibHeterocyclic Compounds, 3-RingInterferon-gammaInterferon Type IJAK1 protein, humanJak1 protein, mouseJanus Kinase 1Janus Kinase InhibitorsPiperidinesPurinesPyrazolesPyrimidinesSTAT1 Transcription FactorSulfonamidestofacitinibupadacitinib
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.