Evidence map›Paper›PMID 39415005›Full record

ArticleNature2024

Selective utilization of glucose metabolism guides mammalian gastrulation.

Dominica Cao, Jenna Bergmann, Liangwen Zhong, Anupama Hemalatha, Chaitanya Dingare, Tyler Jensen, Andy L Cox, Valentina Greco, Benjamin Steventon, Berna Sozen

Abstract read
In one paragraph

Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed.

  1. Review
  2. The Role of Glucose Metabolism inInternational journal of molecular sciences · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Timing of NAD Deficiency During Organogenesis Dictates Defect Type and Penetrance.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Dominica Cao *Department of Genetics, Yale School of Medicine, Yale University, New Haven, CT, USA.
Jenna Bergmann *Department of Genetics, Yale School of Medicine, Yale University, New Haven, CT, USA.
Liangwen ZhongDepartment of Genetics, Yale School of Medicine, Yale University, New Haven, CT, USA.ORCID 0000-0002-5397-3880
Anupama HemalathaDepartment of Genetics, Yale School of Medicine, Yale University, New Haven, CT, USA.
Chaitanya DingareDepartment of Genetics, University of Cambridge, Downing Site, Cambridge, UK.
Tyler JensenDepartment of Genetics, Yale School of Medicine, Yale University, New Haven, CT, USA.ORCID 0000-0003-0220-4026
Andy L CoxDepartment of Genetics, Yale School of Medicine, Yale University, New Haven, CT, USA.ORCID 0000-0002-9394-5702
Valentina GrecoDepartment of Genetics, Yale School of Medicine, Yale University, New Haven, CT, USA.ORCID 0000-0002-6492-4603
Benjamin SteventonDepartment of Genetics, University of Cambridge, Downing Site, Cambridge, UK.ORCID 0000-0001-7838-839X
Berna SozenDepartment of Genetics, Yale School of Medicine, Yale University, New Haven, CT, USA. berna.sozen@yale.edu.ORCID 0000-0001-5834-5819

Funding

Live Imaging of Skin RegenerationR01AR063663 · NIAMS · YALE UNIVERSITY · PI Valentina Greco · 2012 to 2026
$7.7M
Defining the role of mutational burden in sustaining normal homeostasis during agingDP1AG066590 · NIA · YALE UNIVERSITY · PI GRECO, VALENTINA · 2019 to 2023
$5.9M
Deciphering Principles of Human Embryonic Patterning in Development and DiseaseDP2HD112040 · NICHD · YALE UNIVERSITY · PI SOZEN, BERNA · 2022 to 2025
$2.5M
Normal stem cells and their transition to disease in the skinR01AR067755 · NIAMS · YALE UNIVERSITY · PI GRECO, VALENTINA · 2016 to 2020
$2.2M
NIAMS NIH HHS R01 AR063663NIAMS NIH HHS R01 AR067755NIA NIH HHS DP1 AG066590NICHD NIH HHS DP2 HD112040Wellcome Trust
6 · The paper itself

Abstract

The prevailing dogma for morphological patterning in developing organisms argues that the combined inputs of transcription factor networks and signalling morphogens alone generate spatially and temporally distinct expression patterns. However, metabolism has also emerged as a critical developmental regulator

Indexed as

Embryo, MammalianGastrulationGlucoseSingle-Cell AnalysisAnimalsBiosynthetic PathwaysCell LineageCell MovementExtracellular Signal-Regulated MAP KinasesFemaleGerm LayersGlycolysisHexosaminesMaleMesodermMiceExtracellular Signal-Regulated MAP KinasesGlucoseHexosamines

Identifiers

PMID39415005
PMCPMC11499262

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.