ArticleNature communications2024
Spatiotemporal cerebral blood flow dynamics underlies emergence of the limbic-sensorimotor-association cortical gradient in human infancy.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed.
- Developmental human brain connectome from fetal stage to early childhood.Developmental cognitive neuroscience · 2026Review
- Multimodal Assessment of Cerebral Perfusion and EEG Maturation in Preterm Infants at Term-Equivalent Age.Children (Basel, Switzerland) · 2026Article
- Functional changes of precuneus architecture across newborns, infants, and early adolescents.Scientific reports · 2026Article
- Hierarchical maturation of structural brain connectomes from birth to childhood.Nature communications · 2026Article
- Human brain R2* transitions across birth from the womb to early infancy.Communications biology · 2025Article
- Decreased Cerebral Blood Flow in Young Children With Prenatal Alcohol Exposure.Biological psychiatry global open science · 2025Article
- High-Fidelity MRI Assessment of Cerebral Perfusion in Healthy Neonates Less Than 1 Week of Age.Journal of magnetic resonance imaging : JMRI · 2025Article
- Mapping cerebral blood perfusion and its links to multi-scale brain organization across the human lifespan.PLoS biology · 2025Article
- Article
- Machine-learning based prediction of future outcome using multimodal MRI during early childhood.Seminars in fetal & neonatal medicine · 2024Review
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Abstract
Infant cerebral blood flow (CBF) delivers nutrients and oxygen to fulfill brain energy consumption requirements for the fastest period of postnatal brain development across the lifespan. However, organizing principle of whole-brain CBF dynamics during infancy remains obscure. Leveraging a unique cohort of 100+ infants with high-resolution arterial spin labeled MRI, we find the emergence of the cortical hierarchy revealed by the highest-resolution infant CBF maps available to date. Infant CBF across cortical regions increases in a biphasic pattern featured by initial rapid and subsequently slower rate, and break-point ages increasing along the limbic-sensorimotor-association cortical gradient. Increases in CBF in sensorimotor cortices are associated with enhanced language and motor skills, and frontoparietal association cortices with cognitive skills. The study discovers emergence of the hierarchical limbic-sensorimotor-association cortical gradient in infancy and offers standardized reference of infant brain CBF and insight into the physiological basis of cortical specialization and real-world infant developmental functioning.
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