ArticleScientific reports2024
Association of neutrophil-to-lymphocyte ratio with all-cause and cardiovascular mortality in CVD patients with diabetes or pre-diabetes.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Advanced lung cancer inflammation index and mortality risk in patients with cardiovascular disease.BMC cardiovascular disorders · 2026Article
- Prognostic Value of the Neutrophil-to-Lymphocyte Ratio for All-Cause Mortality in Patients With Cardiovascular-Kidney-Metabolic Stage 4.Mediators of inflammation · 2026Article
- Exploring the link: Hemogram-derived markers in type 2 diabetes mellitus and its complications.World journal of diabetes · 2025Review
- Neutrophil percentage to albumin ratio predicts all-cause and cardiovascular mortality in patients with diabetes or prediabetes from NHANES 1999-2018.Scientific reports · 2025Article
- Interpretable machine learning method to predict the risk of pre-diabetes using a national-wide cross-sectional data: evidence from CHNS.BMC public health · 2025Article
- Neutrophil percentage to albumin ratio predicts cardiovascular and all-cause mortality in diabetes and pre diabetes patients.Scientific reports · 2025Article
- Inflammatory markers as predictors of liver fibrosis in type 2 diabetes patients with metabolic dysfunction-associated fatty liver disease.Frontiers in endocrinology · 2025Article
- Risk factor screening and predictive modeling of time-in-range in patients with T2DM undergoing SIIT therapy.Frontiers in endocrinology · 2025Article
- The association between triglyceride-glucose index and neutrophil-lymphocyte ratio and all-cause mortality in the general US population: NHANES 2001-2018.Frontiers in endocrinology · 2024Article
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10 authors.
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Abstract
The neutrophil-to-lymphocyte ratio (NLR), a simple marker of systemic inflammation, is crucial in the progression of cardiovascular diseases (CVD). Its predictive value for all-cause and cardiovascular mortality in CVD patients with diabetes or pre-diabetes remains unclear. We analyzed 3,780 CVD patients with diabetes or pre-diabetes from the National Health and Nutrition Examination Survey (2001-2018). Kaplan-Meier survival curves, weighted Cox proportional hazards models, and restricted cubic spline (RCS) analyses were used to assess the relationship between NLR and mortality risk. RCS revealed a U-shaped association between NLR and all-cause mortality, with an inflection point at 1.776. For NLR < 1.776, the risk of all-cause mortality decreased by 13% per unit increase in NLR (HR: 0.87, 95% CI: 0.76-0.98). For NLR ≥ 1.776, the risk increased by 15% per unit increase (HR: 1.15, 95% CI: 1.10-1.26). A positive linear association was found between NLR and cardiovascular mortality, with a 17% increase in risk per unit increase in NLR (HR: 1.17, 95% CI: 1.10-1.25). No significant interactions were observed in stratified analyses. Our study revealed the U-shaped relationship between NLR and all-cause mortality, and a positive linear relationship with cardiovascular mortality in CVD patients with diabetes or pre-diabetes.
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