ArticleNature communications2024
Expectancy-related changes in firing of dopamine neurons depend on hippocampus.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Reward-tethered place cells support flexible magnitude coding and remapping in the hippocampus.bioRxiv : the preprint server for biology · 2026Article
- Dopaminergic responses to identity prediction errors depend differently on the orbitofrontal cortex and hippocampus.Behavioral neuroscience · 2026Article
- Article
- The devilish details affecting TDRL models in dopamine research.Trends in cognitive sciences · 2025Review
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6 authors.
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Abstract
The orbitofrontal cortex (OFC) and hippocampus (HC) both contribute to the cognitive maps that support flexible behavior. Previously, we used the dopamine neurons to measure the functional role of OFC. We recorded midbrain dopamine neurons as rats performed an odor-based choice task, in which expected rewards were manipulated across blocks. We found that ipsilateral OFC lesions degraded dopaminergic prediction errors, consistent with reduced resolution of the task states. Here we have repeated this experiment in male rats with ipsilateral HC lesions. The results show HC also shapes the task states, however unlike OFC, which provides information local to the trial, the HC is necessary for estimating upper-level hidden states that distinguish blocks. The results contrast the roles of the OFC and HC in cognitive mapping and suggest that the dopamine neurons access rich information from distributed regions regarding the environment's structure, potentially enabling this teaching signal to support complex behaviors.
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