Evidence map›Paper›PMID 39414770›Full record

ArticleNature communications2024

Generalizable and automated classification of TNM stage from pathology reports with external validation.

Jenna Kefeli, Jacob Berkowitz, Jose M Acitores Cortina, Kevin K Tsang, Nicholas P Tatonetti

Abstract readValidation Study
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  18. Applications of Large Language Models in Pathology.Bioengineering (Basel, Switzerland) · 2024
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Jenna KefeliDepartment of Systems Biology, Columbia University, New York, NY, USA.
Jacob Berkowitz *Department of Computational Biomedicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Jose M Acitores Cortina *Department of Computational Biomedicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID 0009-0007-0361-9334
Kevin K Tsang *Department of Computational Biomedicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Nicholas P TatonettiDepartment of Systems Biology, Columbia University, New York, NY, USA. nicholas.tatonetti@cshs.org.ORCID 0000-0002-2700-2597

Funding

Precision Pharmacology and Pharmacovigilance: Leveraging AI to address drug safety knowledge gapsR35GM131905 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Nicholas P Tatonetti · 2019 to 2026
$3.3M
NIGMS NIH HHS R35 GM131905
6 · The paper itself

Abstract

Cancer staging is an essential clinical attribute informing patient prognosis and clinical trial eligibility. However, it is not routinely recorded in structured electronic health records. Here, we present BB-TEN: Big Bird - TNM staging Extracted from Notes, a generalizable method for the automated classification of TNM stage directly from pathology report text. We train a BERT-based model using publicly available pathology reports across approximately 7000 patients and 23 cancer types. We explore the use of different model types, with differing input sizes, parameters, and model architectures. Our final model goes beyond term-extraction, inferring TNM stage from context when it is not included in the report text explicitly. As external validation, we test our model on almost 8000 pathology reports from Columbia University Medical Center, finding that our trained model achieved an AU-ROC of 0.815-0.942. This suggests that our model can be applied broadly to other institutions without additional institution-specific fine-tuning.

Indexed as

Electronic Health RecordsNeoplasmsNeoplasm StagingAlgorithmsHumans

Identifiers

PMID39414770
PMCPMC11484761

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.