Evidence map›Paper›PMID 39414747›Full record

ArticleJournal of the Association for Research in Otolaryngology : JARO2024

Investigating the Effect of Blurring and Focusing Current in Cochlear Implant Users with the Panoramic ECAP Method.

Charlotte Garcia, Charlotte Morse-Fortier, François Guérit, Scott Hislop, Tobias Goehring, Robert P Carlyon, Julie G Arenberg

Abstract read
In one paragraph

Article in Journal of the Association for Research in Otolaryngology : JARO, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Charlotte GarciaCambridge Hearing Group, MRC Cognition & Brain Sciences Unit, University of Cambridge, 15 Chaucer Road, Cambridge, CB27EF, UK. charlotte.garcia@mrc-cbu.cam.ac.uk.ORCID http://orcid.org/0000-0003-0370-3927
Charlotte Morse-FortierEaton Peabody Laboratories (EPL), Massachusetts Eye and Ear, Harvard Medical School, 243 Charles Street, Boston, MA, 02114, USA.
François GuéritCambridge Hearing Group, MRC Cognition & Brain Sciences Unit, University of Cambridge, 15 Chaucer Road, Cambridge, CB27EF, UK.
Scott HislopCambridge Hearing Group, MRC Cognition & Brain Sciences Unit, University of Cambridge, 15 Chaucer Road, Cambridge, CB27EF, UK.
Tobias GoehringCambridge Hearing Group, MRC Cognition & Brain Sciences Unit, University of Cambridge, 15 Chaucer Road, Cambridge, CB27EF, UK.
Robert P CarlyonCambridge Hearing Group, MRC Cognition & Brain Sciences Unit, University of Cambridge, 15 Chaucer Road, Cambridge, CB27EF, UK.
Julie G ArenbergEaton Peabody Laboratories (EPL), Massachusetts Eye and Ear, Harvard Medical School, 243 Charles Street, Boston, MA, 02114, USA.

Funding

International Project Grant (GB) G82Medical Research Council MR/T03095X/1Wellcome TrustWellcome Trust RG91976
6 · The paper itself

Abstract

purposeFor some cochlear implants (CIs), it is possible to focus electrical stimulation by partially returning current from the active electrode to nearby, intra-cochlear electrodes (partial tripolar (pTP) stimulation). Another method achieves the opposite: "blurring" by stimulating multiple electrodes simultaneously. The Panoramic ECAP (PECAP) method provides a platform to investigate their effects in detail by measuring electrically evoked compound action potentials and estimating current spread and neural responsiveness along the length of the CI electrode array. We investigate how sharpening and broadening the electrical current spread are reflected in PECAP estimates.

methodsPECAP measurements were recorded at most comfortable level in 12 ears of Advanced Bionics CI users. Focused thresholds were also determined. For the electrodes with the highest and lowest focused thresholds, additional PECAP measurements were recorded while stimulating in pTP mode and in "blurred" mode with 3 or 5 adjacent electrodes simultaneously stimulated. Current spread and neural responsiveness were then estimated along the electrode array using PECAP.

resultsPECAP revealed increased current spread estimates across participants for blurred stimulation of the targeted electrodes towards the apex of the cochlea. Variable results for pTP stimulation were found, with two of eight ears appearing to drive a small group-level effect of increased current spread.

conclusionWhen stimulating multiple electrodes simultaneously, PECAP detected localized increases in current spread towards the apex (but not the base) of the cochlea. pTP stimulation showed mixed effects on PECAP current spread estimates. These findings are in line with behavioral speech perception studies and have implications for cochlear implant optimization.

Indexed as

Cochlear ImplantsAdultAgedElectric StimulationFemaleHumansMaleMiddle AgedBlurred stimulationCochlear implantCurrent spreadElectrically evoked compound action potential (ECAP)Focused stimulationNeural responsiveness

Identifiers

PMID39414747
PMCPMC11683039

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.