Evidence map›Paper›PMID 39414708›Full record

ArticleIntensive care medicine experimental2024

A self-regulated expiratory flow device for mechanical ventilation: a bench study.

Lianye Yang, Ubbo F Wiersema, Shailesh Bihari, Roy Broughton, Andy Roberts, Nigel Kelley, Mark McEwen

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Article in Intensive care medicine experimental, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lianye YangBiomedical Engineering Department, Flinders Medical Centre, South Adelaide Local Health Network, Adelaide, SA, Australia.
Ubbo F WiersemaIntensive and Critical Care Unit, Flinders Medical Centre, South Adelaide Local Health Network, Flinders Lane, Bedford Park, Adelaide, SA, 5042, Australia.
Shailesh BihariIntensive and Critical Care Unit, Flinders Medical Centre, South Adelaide Local Health Network, Flinders Lane, Bedford Park, Adelaide, SA, 5042, Australia. Shailesh.Bihari@sa.gov.au.ORCID http://orcid.org/0000-0001-7553-8620
Roy BroughtonBiomedical Engineering Department, Flinders Medical Centre, South Adelaide Local Health Network, Adelaide, SA, Australia.
Andy RobertsBiomedical Engineering Department, Flinders Medical Centre, South Adelaide Local Health Network, Adelaide, SA, Australia.
Nigel KelleyBiomedical Engineering Department, Flinders Medical Centre, South Adelaide Local Health Network, Adelaide, SA, Australia.
Mark McEwenBiomedical Engineering Department, Flinders Medical Centre, South Adelaide Local Health Network, Adelaide, SA, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionUnregulated expiratory flow may contribute to ventilator-induced lung injury. The amount of energy dissipated into the lungs with tidal mechanical ventilation may be used to quantify potentially injurious ventilation. Previously reported devices for variable expiratory flow regulation (FLEX) require, either computer-controlled feedback, or an initial expiratory flow trigger. In this bench study we present a novel passive expiratory flow regulation device.

methodsThe device was tested using a commercially available mechanical ventilator with a range of settings (tidal volume 420 ml and 630 ml, max. inspiratory flow rate 30 L/min and 50 L/min, respiratory rate 10 min

resultsMaximal and minimal reduction in peak expiratory flow was from 97.18 ± 0.41 L/min to 25.82 ± 0.07 L/min (p < 0.001), and from 44.11 ± 0.42 L/min to 26.30 ± 0.06 L/min, respectively. Maximal prolongation in expiratory time was recorded from 1.53 ± 0.06 s to 3.64 ± 0.21 s (p < 0.001). As a result of the extended expiration, the maximal decrease in I:E ratio was from 1:1.15 ± 0.03 to 1:2.45 ± 0.01 (p < 0.001). The greatest increase in mean airway pressure was from 10.04 ± 0.03 cmH

conclusionsThe device bench tested in this study demonstrated a significant reduction in peak expiratory flow rate and dissipated energy, compared to ventilation with unregulated expiratory flow. Application of the device warrants further experimental and clinical evaluation.

Indexed as

Energy dissipationExpiratory resistive loadFlow-controlled expirationMandatory ventilation

Identifiers

PMID39414708
PMCPMC11484996

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.