Evidence map›Paper›PMID 39414685›Full record

ArticleBlood research2024

Absence of canonical mutations in pediatric essential thrombocytosis: a case series.

Jae Wook Lee, Suejung Jo, Jae Won Yoo, Seongkoo Kim, Nack-Gyun Chung, Bin Cho

Abstract readLetter
PubMed Full text at PMC Publisher
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Article in Blood research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Jae Wook LeeDivision of Pediatric Hematology and Oncology, Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. dashwood@catholic.ac.kr.
Suejung JoDivision of Pediatric Hematology and Oncology, Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Jae Won YooDivision of Pediatric Hematology and Oncology, Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Seongkoo KimDivision of Pediatric Hematology and Oncology, Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Nack-Gyun ChungDivision of Pediatric Hematology and Oncology, Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Bin ChoDivision of Pediatric Hematology and Oncology, Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Essential thrombocytosis (ET) is a rare myeloproliferative disease in children, and there are few standard management guidelines. We herein report a case series of 10 pediatric patients with ET diagnosed at our institution over a period of 13 years. All patients fulfilled the World Health Organization diagnostic criteria for ET, and none harbored the canonical ET mutations JAK2 V617F, CALR, or MPL. Overall, 7 of the 10 patients received treatment for ET, and during follow-up, 3 of these 7 patients discontinued cytoreductive therapy. No patient experienced hemorrhagic or thrombotic complications. Our case series emphasizes that the genetic features of pediatric ET may differ significantly from those of adult ET, and that treatment cessation is a possibility for some patients.

Identifiers

PMID39414685
PMCPMC11484992

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