ArticleAesthetic plastic surgery2025
A New Approach with Combined Microneedle and Sublative Fractional Radiofrequency for Photoaging Management: A Clinical, Histometric, and Immunohistochemical Study.
Article in Aesthetic plastic surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Improving Striae Distensae With Combined Hyperdiluted Calcium Hydroxylapatite Injection and Fractional Microneedling Radiofrequency: A Pilot Study.Aesthetic surgery journal. Open forum · 2026Article
- Radiofrequency technology as an anti-aging intervention: clinical efficacy in reversing senescence-driven skin laxity and age-related dermal degeneration.Frontiers in cell and developmental biology · 2026Article
- Comparison of the efficacy and safety of 755-nm picosecond alexandrite laser with diffractive lens array vs. fractional microneedle radiofrequency for the treatment of facial photoaging: a retrospective study.Frontiers in medicine · 2026Article
- Review
- Preventive and Therapeutic Interventions in Solar Elastosis and Photoaging: A Comprehensive Systematic Review.Biomedicines · 2025Review
- A Scoping Review of Radiofrequency Microneedling: Clinical Application and Outcome Assessment.Aesthetic plastic surgery · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFractional radiofrequency (FRF) has been reported to be effective in improving wrinkles. A combination of microneedle and sublative fractional radiofrequency (SFRF) may have the potential synergy to improve photoaged skin.
objectivesTo evaluate the efficacy and safety of combined microneedle and SFRF in photoaging management.
methodsThis prospective study included 12 subjects with moderate photoaging (skin phototype III-IV). The subjects received three consecutive combined microneedle and sublative FRF at 1-month intervals. Punch biopsies were obtained before and after three months of treatment. Routine H&E, Masson-trichrome, Orcein staining, histometric measurements, as well as Collagen type I and Elastin immunohistochemical staining were performed.
resultsSignificant improvement was noticed regarding skin tightening and texture (p < 0.05), rhytides, and volunteers' satisfaction (p < 0.001). Collagen fibers appeared better organized, with a significant increase in collagen type I (p = 0.001). Meanwhile, normal-appearing elastic fibers were restored, and a significant reduction in abnormal elastin was achieved (p = 0.0005).
conclusionCombined microneedle and sublative FRF may provide a new therapeutic approach for photoaged skin. LEVEL OF EVIDENCE II: For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
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Registered trials
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