Evidence map›Paper›PMID 39414393›Full record

ArticleEarly intervention in psychiatry2025

Tunisian Adolescents at CHR for Psychosis: A Pilot Study of Cognitive Remediation in a LMIC.

Zeineb Abbes, Sana Taleb, Houda Ben Yahia, Hajer Hmidi, Melek Hajri, Selima Jelili, Soumeya Halayem, Ali Mrabet, Joseph Ventura, Asma Bouden

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Early intervention in psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zeineb AbbesChild and Adolescent Psychiatric Department, Razi University Hospital, Tunis, Tunisia.
Sana TalebChild and Adolescent Psychiatric Department, Razi University Hospital, Tunis, Tunisia.
Houda Ben YahiaChild and Adolescent Psychiatric Department, Razi University Hospital, Tunis, Tunisia.
Hajer HmidiChild and Adolescent Psychiatric Department, Razi University Hospital, Tunis, Tunisia.
Melek HajriChild and Adolescent Psychiatric Department, Razi University Hospital, Tunis, Tunisia.
Selima JeliliChild and Adolescent Psychiatric Department, Razi University Hospital, Tunis, Tunisia.ORCID 0000-0002-6265-1795
Soumeya HalayemChild and Adolescent Psychiatric Department, Razi University Hospital, Tunis, Tunisia.
Ali MrabetFaculty of Medicine of Tunis, El-Manar Tunis University, Tunis, Tunisia.
Joseph VenturaUCLA Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, California, USA.ORCID 0000-0002-9242-7903
Asma BoudenChild and Adolescent Psychiatric Department, Razi University Hospital, Tunis, Tunisia.

Funding

Enhancing Cognitive Training Through Exercise Following a First Schizophrenia EpisodeR01MH110544 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI NUECHTERLEIN, KEITH H · 2016 to 2022
$7.3M
Cognitive Training vs. Treatment as Usual to Improve Functioning and Reduce Transition Rates in Tunisian CHR Youth: A Feasibility StudyR21MH131319 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI OUALI, UTA INGEBURG, VENTURA, JOSEPH · 2023 to 2023
$361k
NIMH NIH HHS R01 MH110544NIMH NIH HHS R21 MH131319
6 · The paper itself

Abstract

backgroundClinical high risk (CHR) youth are known to exhibit cognitive deficits at similar levels to their more severally ill counter parts. Cognitive training (CT) programs offer a promising method for early intervention and the prevention of further cognitive decline in this vulnerable population. However, there are few structured CT intervention programs addressing the needs of CHR youth in LMICs of the Middle East.

methodsWe conducted a study in the Child and Adolescent Psychiatry Department of Razi University Hospital. Patients were assessed by trained raters with the "Comprehensive Assessment of At-Risk Mental States" to confirm their CHR status. Cognitive Training (CT) was combined with the Neuropsychological Educational Approach to Remediation (CT-NEAR) as part of a social rehabilitation program. We enrolled 25 CHR patients and examined several domains of cognitive functioning and evaluated daily functioning prior to starting the intervention and after completion.

resultsThere were 20 patients who completed the study. The CT-NEAR group (n = 10) completed an average number 28.33 sessions over 12 weeks, which were matched for therapist time with the TAU group (n = 10). We found statistically significant improvements in CT-NEAR versus TAU in several cognitive domains; such as cognitive flexibility, memory-short and long-term, and verbal fluency. Also, CT-NEAR versus TAU patients improved in global functioning.

conclusionsOur findings indicate that cognitive remediation versus TAU for Tunisian CHR youth is feasible and effective especially in improving cognitive functioning when delivered in a social rehabilitation context (Bridging Group) and extends to global level of functioning.

Indexed as

Cognitive DysfunctionCognitive RemediationPsychotic DisordersAdolescentFemaleHumansMalePilot ProjectsTreatment OutcomeTunisiaadolescentsBridging Groupsclinical high riskcognitive remediationglobal functioningLMICMENATunisia

Identifiers

PMID39414393
PMCPMC11730502

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.