Evidence map›Paper›PMID 39414384›Full record

ArticleJournal of neuroendocrinology2025

Activation of ionotropic and group I metabotropic glutamate receptors stimulates kisspeptin neuron activity in mice.

Robin J Bearss, Isabella A Oliver, Peighton N Neuman, Wahab I Abdulmajeed, Jennifer M Ackerman, Richard Piet

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroendocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Robin J BearssSchool of Biomedical Sciences, Kent State University, Kent, Ohio, USA.ORCID 0009-0005-5475-0696
Isabella A OliverBrain Health Research Institute, Kent State University, Kent, Ohio, USA.
Peighton N NeumanBrain Health Research Institute, Kent State University, Kent, Ohio, USA.
Wahab I AbdulmajeedBrain Health Research Institute, Kent State University, Kent, Ohio, USA.
Jennifer M AckermanSchool of Biomedical Sciences, Kent State University, Kent, Ohio, USA.
Richard PietSchool of Biomedical Sciences, Kent State University, Kent, Ohio, USA.ORCID 0000-0001-5160-6027

Funding

Suprachiasmatic nucleus to kisspeptin circuit in the circadian control of reproductionR01HD109337 · NICHD · KENT STATE UNIVERSITY · PI Richard Piet · 2023 to 2026
$1.4M
National Institute of Child Health and Human Development R01HD109337NICHD NIH HHS R01 HD109337
6 · The paper itself

Abstract

Different populations of hypothalamic kisspeptin (KISS1) neurons located in the rostral periventricular area of the third ventricle (RP3V) and arcuate nucleus (ARC) are thought to generate the sex-specific patterns of gonadotropin secretion. These neuronal populations integrate gonadal sex steroid feedback with internal and external cues relayed via the actions of neurotransmitters and neuropeptides. The excitatory amino acid neurotransmitter glutamate, the main excitatory neurotransmitter in the brain, plays a role in regulating gonadotropin secretion, at least partially through engaging KISS1 signaling. The expression and function of individual glutamate receptor subtypes in KISS1 neurons, however, are not well characterized. Here, we used GCaMP-based calcium imaging and patch-clamp electrophysiology to assess the impact of activating individual ionotropic (iGluR) and group I metabotropic (mGluR) glutamate receptors on KISS1 neuron activity in the mouse RP3V and ARC. Our results indicate that activation of all iGluR subtypes and of group I mGluRs, likely mGluR1, consistently drives activity in the majority of KISS1 neurons within the RP3V and ARC of males and females. Our results also revealed, somewhat unexpectedly, sex- and region-specific differences. Indeed, activating (S)-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) type iGluRs evoked larger responses in female ARC

Indexed as

KisspeptinsNeuronsReceptors, Ionotropic GlutamateReceptors, Metabotropic GlutamateAnimalsArcuate Nucleus of HypothalamusFemaleMaleMiceMice, Inbred C57BLKiss1 protein, mouseKisspeptinsmetabotropic glutamate receptor type 1Receptors, Ionotropic GlutamateReceptors, Metabotropic Glutamatecalcium imagingelectrophysiologyfertilityGCaMPGnRH

Identifiers

PMID39414384
PMCPMC11750333

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.