Evidence map›Paper›PMID 39414359›Full record

ArticleJournal of psychiatry & neuroscience : JPN

Spatial transcriptomic analysis of adult hippocampal neurogenesis in the human brain.

Sophie Simard, Reza Rahimian, Maria Antonietta Davoli, Stéphanie Théberge, Natalie Matosin, Gustavo Turecki, Corina Nagy, Naguib Mechawar

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of psychiatry & neuroscience : JPN. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Reduced Adult Neurogenesis in Humans Results From a Tradeoff Rather Than Direct Negative Selection.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025
    Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sophie SimardFrom the McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montréal, Que. (Simard, Rahimian, Antonietta, Théberge, Turecki, Nagy, Mechawar); the School of Medical Sciences, Faculty of Medicine and Health, Charles Perkins Centre, The University of Sydney, Camperdown, Australia (Matosin); the Department of Psychiatry, McGill University, Montréal, Que. (Turecki, Nagy, Mechawar).
Reza RahimianFrom the McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montréal, Que. (Simard, Rahimian, Antonietta, Théberge, Turecki, Nagy, Mechawar); the School of Medical Sciences, Faculty of Medicine and Health, Charles Perkins Centre, The University of Sydney, Camperdown, Australia (Matosin); the Department of Psychiatry, McGill University, Montréal, Que. (Turecki, Nagy, Mechawar).
Maria Antonietta DavoliFrom the McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montréal, Que. (Simard, Rahimian, Antonietta, Théberge, Turecki, Nagy, Mechawar); the School of Medical Sciences, Faculty of Medicine and Health, Charles Perkins Centre, The University of Sydney, Camperdown, Australia (Matosin); the Department of Psychiatry, McGill University, Montréal, Que. (Turecki, Nagy, Mechawar).
Stéphanie ThébergeFrom the McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montréal, Que. (Simard, Rahimian, Antonietta, Théberge, Turecki, Nagy, Mechawar); the School of Medical Sciences, Faculty of Medicine and Health, Charles Perkins Centre, The University of Sydney, Camperdown, Australia (Matosin); the Department of Psychiatry, McGill University, Montréal, Que. (Turecki, Nagy, Mechawar).
Natalie MatosinFrom the McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montréal, Que. (Simard, Rahimian, Antonietta, Théberge, Turecki, Nagy, Mechawar); the School of Medical Sciences, Faculty of Medicine and Health, Charles Perkins Centre, The University of Sydney, Camperdown, Australia (Matosin); the Department of Psychiatry, McGill University, Montréal, Que. (Turecki, Nagy, Mechawar).
Gustavo TureckiFrom the McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montréal, Que. (Simard, Rahimian, Antonietta, Théberge, Turecki, Nagy, Mechawar); the School of Medical Sciences, Faculty of Medicine and Health, Charles Perkins Centre, The University of Sydney, Camperdown, Australia (Matosin); the Department of Psychiatry, McGill University, Montréal, Que. (Turecki, Nagy, Mechawar).
Corina NagyFrom the McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montréal, Que. (Simard, Rahimian, Antonietta, Théberge, Turecki, Nagy, Mechawar); the School of Medical Sciences, Faculty of Medicine and Health, Charles Perkins Centre, The University of Sydney, Camperdown, Australia (Matosin); the Department of Psychiatry, McGill University, Montréal, Que. (Turecki, Nagy, Mechawar).
Naguib MechawarFrom the McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montréal, Que. (Simard, Rahimian, Antonietta, Théberge, Turecki, Nagy, Mechawar); the School of Medical Sciences, Faculty of Medicine and Health, Charles Perkins Centre, The University of Sydney, Camperdown, Australia (Matosin); the Department of Psychiatry, McGill University, Montréal, Que. (Turecki, Nagy, Mechawar). naguib.mechawar@mcgill.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAdult hippocampal neurogenesis has been extensively characterized in rodent models, but its existence in humans remains controversial. We sought to assess the phenomenon in postmortem human hippocampal samples by combining spatial transcriptomics and multiplexed fluorescent in situ hybridization.

methodsWe computationally examined the spatial expression of various canonical neurogenesis markers in postmortem dentate gyrus (DG) sections from young and middle-aged sudden-death males. We conducted in situ assessment of markers expressed in neural stem cells, proliferative cells, and immature granule neurons in postmortem DG sections from infant, adolescent, and middle-aged males.

resultsWe examined frozen DG tissue from infant ( LIMITATIONS: The study was limited by small sample sizes and included samples only from males.

conclusionOur findings indicate very low levels of hippocampal neurogenesis throughout life and the existence of a local reserve of plasticity in the adult human hippocampus. Overall, our study provides important insight into the distribution and phenotype of cells expressing neurogenesis markers in the adult human hippocampus.

Indexed as

Dentate GyrusNeural Stem CellsNeurogenesisAdolescentAdultCell ProliferationChild, PreschoolDoublecortin ProteinGene Expression ProfilingHippocampusHumansInfantIn Situ Hybridization, FluorescenceMaleMiddle AgedNeuronsDoublecortin Protein

Identifiers

PMID39414359
PMCPMC11495544

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.