ArticleBMJ paediatrics open2024
Analysis and validation of clinical subgroups of Kawasaki disease in children in China: a retrospective study.
Article in BMJ paediatrics open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed.
- Gastrointestinal Symptoms in Kawasaki Disease and Multisystem Inflammatory Syndrome in Children.Pediatric cardiology · 2026Article
- Natural history and long-term outcomes of kawasaki disease following spontaneous defervescence: 31 years of experience from North India.Immunologic research · 2026Article
- Subgroups of Kawasaki disease in Japanese patients and temporal change: a retrospective data-driven cluster analysis.Clinical rheumatology · 2026Article
- Construction and subgroup validation of a predictive model for IVIG-resistance in kawasaki disease.Frontiers in cardiovascular medicine · 2026Article
- Decoding clinical heterogeneity and age-related coronary risk in incomplete Kawasaki disease: a multicenter cluster analysis and structural equation modeling study.Frontiers in immunology · 2026Article
- Exploring ferroptosis-associated immune characteristics in Kawasaki disease through bioinformatics.Scientific reports · 2025Article
- A retrospective cohort study using machine learning to predict coronary artery lesions in children with Kawasaki disease.BMC pediatrics · 2025Article
- Risk factors associated with persistent coronary artery lesions in children with Kawasaki disease in an Italian cohort.European journal of pediatrics · 2025Article
- A risk stratification model for coronary artery lesions in Kawasaki disease: focus on subgroup-specific utility.Frontiers in cardiovascular medicine · 2025Article
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13 authors.
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Abstract
objectiveAlthough Kawasaki disease (KD) is commonly regarded as a single disease entity, clinical subgroups have recently been described. We aimed to validate previous research on clinical subgroups and establish a KD subgroup differentiation model specific to China.
methodsWe analysed clinical data of 1682 patients diagnosed with KD at the Kunming Children's Hospital from December 2014 to December 2022. We performed principal component analysis and hierarchical clustering on 13 continuous variables. Then, we grouped the patients based on the optimal number of clusters and analysed the clinical characteristics of each subgroup.
resultsWe ultimately identified three subgroups. In cluster 1, younger patients predominantly exhibited the highest risk of coronary artery aneurysm and the lowest rate of intravenous immunoglobulin resistance. Cluster 2 was characterised by high inflammatory markers and a lowered risk of coronary artery aneurysm. Cluster 3 was characterised by liver involvement, with significant elevations in liver enzymes, gamma-glutamyl transferase and total bilirubin. We found a positive correlation between the ratio of the rising trend and intravenous immunoglobulin resistance. Cluster 1 and cluster 3 shared similarities with the previously identified younger age subgroup and liver subgroup, respectively, whereas cluster 2 was unique to our study.
conclusionsOur study preliminarily validated a previous KD subgroup study and established a KD subgroup model in China.
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