Evidence map›Paper›PMID 39414229›Full record

ArticleJournal of advanced research2025

Metabolic responses of sea anemone and jellyfish to temperature and UV bleaching: Insights into stress adaptation using LCMS-based metabolomics, molecular networking and chemometrics.

Mohamed A Farag, Doaa B Saied, Sherif M Afifi, Andreas Kunzmann, Ludger A Wessjohann, Hildegard Westphal, Holger Kühnhold, Marleen Stuhr

Abstract read
In one paragraph

Article in Journal of advanced research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Cnidarian toxins: omics approaches and recombinant proteins.The journal of venomous animals and toxins including tropical diseases · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mohamed A FaragPharmacognosy Department, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt. Electronic address: mohamed.farag@pharma.cu.edu.eg.
Doaa B SaiedChemistry Department, School of Sciences and Engineering, The American University in Cairo, New Cairo 11835, Egypt.
Sherif M AfifiDepartment for Life Quality Studies, Rimini Campus, University of Bologna, Corso d'Augusto 237, Rimini 47921, Italy.
Andreas KunzmannLeibniz Centre for Tropical Marine Research (ZMT), Fahrenheit Str. 6, Bremen 28359, Germany.
Ludger A WessjohannDepartment of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry (IPB), Weinberg 3, Halle (Saale) 06120, Germany.
Hildegard WestphalLeibniz Centre for Tropical Marine Research (ZMT), Fahrenheit Str. 6, Bremen 28359, Germany; Department of Geosciences, University of Bremen, Bremen 28359, Germany.
Holger KühnholdLeibniz Centre for Tropical Marine Research (ZMT), Fahrenheit Str. 6, Bremen 28359, Germany.
Marleen StuhrLeibniz Centre for Tropical Marine Research (ZMT), Fahrenheit Str. 6, Bremen 28359, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionClimate change poses various threats to marine life, particularly in shallow tropical waters.

objectiveThe impact of increased temperature and ultraviolet (UV) exposure on two photosymbiotic cnidarians, a common bubble-tip anemone and an upside-down jellyfish, was investigated.

methodsTo illustrate the response of aquatic organisms, the metabolomes of unstressed Entacmaea quadricolor and Cassiopea andromeda were compared for detailed metabolite profiling. UHPLC-MS coupled with chemometrics and GNPS molecular networking was employed for sample classification and identification of markers unique to stress responses in each organism.

resultsSeveral compounds with bioactive functions, including peptides and terpenoids, were reported for the first time in both organisms, viz. cyclic tetraglutamate, campestriene, and ceramide aminoethyl phosphonate (CEAP d18:2/16:0). Both anemone and jellyfish were subjected to either elevated UV-B light intensity up to 6.6 KJ m

conclusionThis study presents several bioinformatic tools for the first time in two cnidarian organisms to provide not only a broader coverage of their metabolome but also broader insights into cnidarian bleaching in response to different stressors, i.e., heat and UV light, by comparing their effects in anemone versus jellyfish.

Indexed as

Adaptation, PhysiologicalMetabolomicsScyphozoaSea AnemonesStress, PhysiologicalUltraviolet RaysAnimalsChromatography, LiquidMass SpectrometryMetabolomeTemperatureAnemonesBleachingCassiopea andromedaEntacmaea quadricolorGnpsMetabolomicsStress

Identifiers

PMID39414229
PMCPMC12302363

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.