Evidence map›Paper›PMID 39414225›Full record

ReviewJournal of advanced research2025

Ecological consequences of antimicrobial residues and bioactive chemicals on antimicrobial resistance in agroecosystems.

Muhammad Shafiq, Charles Obinwanne Okoye, Mudasir Nazar, Wajid Ali Khattak, Abdelazeem M Algammal

Abstract readReview
In one paragraph

Review in Journal of advanced research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Public health challenges · 2026
    Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Macrolide-resistantFrontiers in pediatrics · 2026
    Article
  10. Review
  11. Article
  12. Antimicrobial Lobophorins from Endophytic StrainMolecules (Basel, Switzerland) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Muhammad ShafiqResearch Institute of Clinical Pharmacy, Department of Pharmacology, Shantou University Medical College, Shantou 515041, China. Electronic address: drshafiq@stu.edu.cn.
Charles Obinwanne OkoyeBiofuels Institute, School of Environment & Safety Engineering, Jiangsu University, Zhenjiang 212013, China; School of Life Sciences, Jiangsu University, Zhenjiang 212013, China; Department of Zoology & Environmental Biology, University of Nigeria, Nsukka 410001, Nigeria.
Mudasir NazarInstitute of Animal Science, Jiangsu Academy of Agricultural Science, Nanjing 210014, China.
Wajid Ali KhattakCollege of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, China.
Abdelazeem M AlgammalDepartment of Bacteriology, Immunology, and Mycology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt. Electronic address: abdelazeem.algammal@vet.suez.edu.eg.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe widespread use of antimicrobials in agriculture, coupled with bioactive chemicals like pesticides and growth-promoting agents, has accelerated the global crisis of antimicrobial resistance (AMR). Agroecosystems provides a platform in the evolution and dissemination of antibiotic-resistant bacteria (ARB) and antibiotic resistance genes (ARGs), which pose significant threats to both environmental and public health. AIM OF REVIEW: This review explores the ecological consequences of antimicrobial residues and bioactive chemicals in agroecosystems, with a focus on their role in shaping AMR. It delves into the mechanisms by which these substances enter agricultural environments, their interactions with soil microbiomes, and the subsequent impacts on microbial community structure. KEY SCIENTIFIC CONCEPTS OF REVIEW: Evidence indicates that the accumulation of antimicrobials promotes resistance gene transfer among microorganisms, potentially compromising ecosystem health and agricultural productivity. By synthesizing current research, we identify critical gaps in knowledge and propose strategies for mitigating the ecological risks associated with antimicrobial residues. Moreover, this review highlights the urgent need for integrated management approaches to preserve ecosystem health and combat the spread of AMR in agricultural settings.

Indexed as

AgricultureAnti-Infective AgentsDrug Resistance, BacterialDrug Resistance, MicrobialEcosystemAnti-Bacterial AgentsBacteriaHumansMicrobiotaSoil MicrobiologyAnti-Bacterial AgentsAnti-Infective AgentsAgroecosystemsAntimicrobial residuesAntimicrobial resistanceBioactive chemicalsEcological risks

Identifiers

PMID39414225
PMCPMC12302514

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.